ISOPTO CARPINE STERILE OPHTHALMIC SOLUTION 2%

SOLUTION

**4.2 Dosage regimen and administration** **Dosage regimen** 2 drops should be instilled in the eye(s) 3 times daily or as directed by a physician. Use in children The safety and efficacy of ISOPTO CARPINE ophthalmic solution in children have not been established. Due to a lack of pharmacokinetic data for the pediatric population, it is not possible to make particular evidence-based dose recommendations for children. Use in patients with hepatic or renal impairment The safety and efficacy of ISOPTO CARPINE ophthalmic solution in patients with hepatic or renal impairment have not been established. Geriatric patients (65 years of age or above) No overall differences in safety and efficacy have been observed between elderly and younger patients. **Method of administration** - For ocular use. - After cap is removed, if tamper evident snap collar is loose, it should be removed before using the product. - To avoid contamination, the dropper tip should not touch any surface. The dropper tip should also not come into contact with the eye as this may cause injury to the eye. Patients should be instructed to keep the bottle tightly closed when not in use. - If more than one topical ophthalmic product is being used, the products must be administered at least 5 minutes apart. Eye ointments should be administered last. - Nasolacrimal occlusion or gently closing the eyelid for 2 minutes after administration is recommended. This may reduce the systemic absorption of medicinal products administered via the ocular route and result in a decrease in systemic adverse reactions.