SELENIUM AGUETTANT CONCENTRATE FOR SOLUTION FOR INFUSION 10 MCG/ML

INFUSION, SOLUTION CONCENTRATE

**4.2. Posology and method of administration** **Posology** 1 ml of solution contains 10 micrograms of selenium. The dose must be adjusted according to the needs of the patient. **The recommended dosage is:** Adults: - Total parenteral nutrition: 60 to 100 micrograms daily. - Selenium deficiency: 100 micrograms (up to a maximum of 400 micrograms) daily for a short period until normalisation of laboratory tests. Paediatric population: - Total parenteral nutrition: - Infants: 2 micrograms/kg/day and infants with low birth weight: 2 to 3 micrograms/kg/day. - Children: 2 to 3 micrograms/kg/day, up to a maximum of 30 micrograms daily. - Adolescents: no data are available. - Selenium deficiency: no data are available Selenium serum levels must be monitored regularly (every 6 to 12 months) in long-term parenteral nutrition and in case of renal impairment or more frequently in case of clinical signs of deficiency. The dose must be adjusted to each individual as a function of the selenium deficiency and the selenium status. **Method of administration** Administration by intravenous route: SELENIUM AGUETTANT concentrate for solution for infusion 10 micrograms/ml must be administered after dilution in solution for parenteral nutrition, after the stability has been validated, or in an isotonic solution (such as 0.9% sodium chloride or 5% glucose) with a slow infusion rate.