Zidovudine

Generic Name
Zidovudine
Brand Names
Combivir, Retrovir, Trizivir
Drug Type
Small Molecule
Chemical Formula
C10H13N5O4
CAS Number
30516-87-1
Unique Ingredient Identifier
4B9XT59T7S
Background

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse tran...

Indication

Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.

Associated Conditions
HIV Transmission, Human Immunodeficiency Virus (HIV) Infections, Perinatal HIV transmission
Associated Therapies
-
Clinical Trials
Related News

The Safety and Effectiveness of Ganciclovir Used Alone or in Combination With Granulocyte-Macrophage Colony Stimulating Factor in the Treatment of Cytomegalovirus (CMV) of the Eye in Patients With AIDS

Not Applicable
Completed
Conditions
HIV Infections
Cytomegalovirus Retinitis
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
50
Registration Number
NCT00000989
Locations
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UCLA CARE Center CRS, Los Angeles, California, United States

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Beth Israel Deaconess - East Campus A0102 CRS, Boston, Massachusetts, United States

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Memorial Sloan-Kettering Cancer Ctr., New York, New York, United States

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A Study of Ritonavir (an Anti-HIV Drug) in HIV-Positive Infants and Children

Phase 1
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
60
Registration Number
NCT00000952
Locations
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Harlem Hosp. Ctr. NY NICHD CRS, New York, New York, United States

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The Children's Hosp. of Philadelphia IMPAACT CRS, Philadelphia, Pennsylvania, United States

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HMS - Children's Hosp. Boston, Div. of Infectious Diseases, Boston, Massachusetts, United States

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Safety and Effectiveness of Ritonavir Plus Lamivudine Plus Zidovudine in HIV-Infected Pregnant Women and Their Babies

Phase 1
Completed
Conditions
HIV Infections
Pregnancy
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
14
Registration Number
NCT00000888
Locations
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Children's Hospital of Michigan NICHD CRS, Detroit, Michigan, United States

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Univ. of Miami Miller School of Medicine - Jackson Memorial Hosp., Miami, Florida, United States

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Univ. of Miami Ped. Perinatal HIV/AIDS CRS, Miami, Florida, United States

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A Treatment IND for Retrovir Brand Zidovudine (AZT) Therapy of Pediatric Patients With HIV Disease

Not Applicable
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2016-10-31
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Registration Number
NCT00000662
Locations
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Glaxo Wellcome Inc, Research Triangle Park, North Carolina, United States

A Study of Zidovudine (AZT) Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Patients With Little or No Previous Treatment

Phase 3
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
3000
Registration Number
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N Texas Ctr for AIDS & Clin Rsch, Dallas, Texas, United States

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Cook County Hosp, Chicago, Illinois, United States

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The Effectiveness of Indinavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients With No Symptoms of Infection

Phase 4
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HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
200
Registration Number
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Locations
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LAC - USC Med Ctr, Los Angeles, California, United States

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Rush Presbyterian - Saint Luke's Med Ctr / Infect Dis, Chicago, Illinois, United States

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Phase 1
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Conditions
HIV Infection
First Posted Date
1999-11-04
Last Posted Date
2017-07-02
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
42
Registration Number
NCT00001644
Locations
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National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

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