Zidovudine
- Generic Name
- Zidovudine
- Brand Names
- Combivir, Retrovir, Trizivir
- Drug Type
- Small Molecule
- Chemical Formula
- C10H13N5O4
- CAS Number
- 30516-87-1
- Unique Ingredient Identifier
- 4B9XT59T7S
- Background
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [PubChem]
- Indication
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
- Associated Conditions
- HIV Transmission, Human Immunodeficiency Virus (HIV) Infections, Perinatal HIV transmission
- Associated Therapies
- -
A Study of Zidovudine in HIV-Infected Patients With Liver Disease
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 39
- Registration Number
- NCT00001001
- Locations
- 🇺🇸
Univ of Massachusetts Med Ctr, Worcester, Massachusetts, United States
🇺🇸Boston Med Ctr, Boston, Massachusetts, United States
🇺🇸Univ of Washington, Seattle, Washington, United States
The Safety and Effectiveness of Hyperimmune Anti-HIV Intravenous Immunoglobulin (HVIG) Plus Zidovudine in HIV-Infected Infants
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 112
- Registration Number
- NCT00000961
A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCP
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 482
- Registration Number
- NCT00000700
- Locations
- 🇺🇸
Johns Hopkins Hosp, Baltimore, Maryland, United States
🇺🇸Harvard (Massachusetts Gen Hosp), Boston, Massachusetts, United States
🇺🇸Beth Israel Deaconess - West Campus, Boston, Massachusetts, United States
The Safety and Effectiveness of Zidovudine in the Treatment of HIV-Infected Children With Mild to Moderate Symptoms
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 224
- Registration Number
- NCT00000990
- Locations
- 🇺🇸
Milton S Hershey Med Ctr, Hershey, Pennsylvania, United States
🇺🇸City Hosp Ctr at Elmhurst / Mount Sinai Hosp, Elmhurst, New York, United States
🇺🇸Bellevue Hosp / New York Univ Med Ctr, New York, New York, United States
A Phase I Evaluation of Azidothymidine (AZT) in Children With Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 12
- Registration Number
- NCT00000701
- Locations
- 🇺🇸
Univ of Miami School of Medicine, Miami, Florida, United States
🇺🇸Duke Univ Med Ctr, Durham, North Carolina, United States
Treatment With Combinations of Several Antiviral Drugs in Infants and Young Children With HIV Infection
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 55
- Registration Number
- NCT00000872
- Locations
- 🇺🇸
Johns Hopkins Hosp. & Health System - Dept. of Peds., Div. of Infectious Diseases, Baltimore, Maryland, United States
🇺🇸Univ. of Maryland Med. Ctr., Div. of Ped. Immunology & Rheumatology, Baltimore, Maryland, United States
🇺🇸BMC, Div. of Ped Infectious Diseases, Boston, Massachusetts, United States
A Study of Zidovudine During Labor and Delivery in HIV-Infected Pregnant Women
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-28
- Target Recruit Count
- 36
- Registration Number
- NCT00000862
- Locations
- 🇺🇸
UCSD Med Ctr / Pediatrics / Clinical Sciences, La Jolla, California, United States
🇺🇸Saint Jude Children's Research Hosp of Memphis, Memphis, Tennessee, United States
🇺🇸Children's Hosp of the King's Daughters, Norfolk, Virginia, United States
The Safety and Effectiveness of Zidovudine in HIV-Infected Pregnant Women and Their Infants
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 1496
- Registration Number
- NCT00000960
- Locations
- 🇺🇸
Los Angeles County - USC Med Ctr, Los Angeles, California, United States
🇵🇷Univ of Puerto Rico / Univ Children's Hosp AIDS, San Juan, Puerto Rico
🇺🇸Univ of Massachusetts Med Ctr, Worcester, Massachusetts, United States
A Multicenter Phase II Double-Blind Exploratory Study to Evaluate Differences Among Various Zidovudine/Didanosine Regimens on Quantitative Measures of Viral Burden in Relatively Early HIV-1 Infection
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-28
- Target Recruit Count
- 85
- Registration Number
- NCT00000823
- Locations
- 🇺🇸
Illinois Masonic Med Ctr, Chicago, Illinois, United States
🇺🇸Harvard (Massachusetts Gen Hosp), Boston, Massachusetts, United States
🇺🇸Univ of Alabama at Birmingham, Birmingham, Alabama, United States
A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 322
- Registration Number
- NCT00000727
- Locations
- 🇺🇸
University of Washington AIDS CRS, Seattle, Washington, United States
🇺🇸Bmc Actg Crs, Boston, Massachusetts, United States
🇺🇸Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis, Indiana, United States
Drug Development Updates
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