Rabeprazole
- Generic Name
- Rabeprazole
- Brand Names
- Aciphex, Pariet
- Drug Type
- Small Molecule
- Chemical Formula
- C18H21N3O3S
- CAS Number
- 117976-89-3
- Unique Ingredient Identifier
- 32828355LL
- Background
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
- Indication
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
- Associated Conditions
- Duodenal Ulcer, Gastric Ulcer, Gastro-esophageal Reflux Disease (GERD), Heartburn, Helicobacter Pylori Infection, Non-erosive Reflux Esophagitis Disease (NERD), Vomiting, Zollinger-Ellison Syndrome, Develop NSAID-induced gastric ulcers, Erosive reflux esophagitis
Comparing the Extent to Which Three Different Formulations of LY4100511 (DC-853) Are Made Available in the Body, Alone and in the Presence of a Drug That Reduces Stomach Acid
- First Posted Date
- 2025-04-08
- Last Posted Date
- 2025-04-18
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 48
- Registration Number
- NCT06916143
- Locations
- 🇺🇸
Clinical Pharmacology of Miami, Miami, Florida, United States
🇺🇸Alliance for Multispecialty Research, LLC, Knoxville, Tennessee, United States
Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib
- Conditions
- Advanced Solid Malignancies
- Interventions
- First Posted Date
- 2025-03-27
- Last Posted Date
- 2025-05-15
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 45
- Registration Number
- NCT06899061
- Locations
- 🇷🇴
Research Site, Cluj Napoca, Romania
Zuojin Wan Combined With Rabeprazole or Mosapride for the Treatment of Functional Dyspepsia Combined With Depression
- Conditions
- Functional DyspepsiaDepression
- Interventions
- First Posted Date
- 2024-07-01
- Last Posted Date
- 2024-07-01
- Target Recruit Count
- 120
- Registration Number
- NCT06481371
Study to Evaluate Safety, Drug Levels, Food and Relative Bioavailability of BMS-986365 in Healthy Adult Male Participants
- First Posted Date
- 2024-05-16
- Last Posted Date
- 2025-03-06
- Lead Sponsor
- Celgene
- Target Recruit Count
- 102
- Registration Number
- NCT06417229
- Locations
- 🇺🇸
Local Institution - 0001, Lenexa, Kansas, United States
The Safety and Tolerability, Pharmacokinetics of TNP-2092 Capsules in Combination With Rabeprazole Sodium Enteric-coated Tablets
- Conditions
- Helicobacter Pylori Infection
- Interventions
- First Posted Date
- 2024-03-29
- Last Posted Date
- 2024-04-01
- Lead Sponsor
- TenNor Therapeutics Inc.
- Target Recruit Count
- 20
- Registration Number
- NCT06337604
- Locations
- 🇨🇳
The First Hospital of Jilin University, Changchun, Jilin, China
A Study to Assess the Potential for Gastric-pH Dependent Drug-Drug Interactions of BIIB122 With a Proton Pump Inhibitor in Healthy Participants
- First Posted Date
- 2024-02-20
- Last Posted Date
- 2024-07-19
- Lead Sponsor
- Biogen
- Target Recruit Count
- 18
- Registration Number
- NCT06264440
- Locations
- 🇺🇸
PPD Development, LP, Austin, Texas, United States
A Study to Learn How a Medicine That Reduces Stomach Acid Affects the Level of Sisunatovir in the Blood of Healthy Adults.
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2023-10-30
- Last Posted Date
- 2025-04-24
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 40
- Registration Number
- NCT06105983
- Locations
- 🇧🇪
Pfizer Clinical Research Unit - Brussels, Brussels, Bruxelles-capitale, Région DE, Belgium
Efficacy and Safety After Multiple Doses of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules in Helicobacter Pylori Infected-positive Participants
- Conditions
- Helicobacter Pylori Infection
- Interventions
- First Posted Date
- 2023-10-11
- Last Posted Date
- 2023-12-12
- Lead Sponsor
- TenNor Therapeutics (Suzhou) Limited
- Target Recruit Count
- 80
- Registration Number
- NCT06076694
- Locations
- 🇨🇳
The First Hospital of Jilin University, Chang chun, Jilin, China
A Study to Evaluate Preliminary Helicobacter Pylori Eradication After Multiple Doses of TNP-2198 Capsules Combined With Rabeprazole Sodium Enteric-coated Tablets, or Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules
- Conditions
- Helicobacter Pylori Infection
- Interventions
- First Posted Date
- 2023-10-11
- Last Posted Date
- 2023-11-22
- Lead Sponsor
- TenNor Therapeutics (Suzhou) Limited
- Target Recruit Count
- 40
- Registration Number
- NCT06076681
- Locations
- 🇨🇳
The First Hospital of Jilin University, Chang chun, Jilin, China
A Study to Investigate the Effects of Acid Reducing Agents on Pharmacokinetics of PC14586 in Healthy Participants
- Conditions
- Healthy Volunteers
- Interventions
- First Posted Date
- 2023-09-26
- Last Posted Date
- 2024-11-13
- Lead Sponsor
- PMV Pharmaceuticals, Inc
- Target Recruit Count
- 28
- Registration Number
- NCT06054464
- Locations
- 🇺🇸
Parexel International, Baltimore, Maryland, United States
Drug Development Updates
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