Sertraline

Generic Name
Sertraline
Brand Names
Zoloft
Drug Type
Small Molecule
Chemical Formula
C17H17Cl2N
CAS Number
79617-96-2
Unique Ingredient Identifier
QUC7NX6WMB
Background

Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as Citalopram and Fluoxetine. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects.
...

Indication

Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety di...

Associated Conditions
Binge Eating Disorder (BED), Bulimia Nervosa, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Panic Disorder, Post Traumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder (SAD)
Associated Therapies
-
Clinical Trials
Related News

Quetiapine XR Versus Sertraline in Acute Bipolar Depression as add-on Therapy

First Posted Date
2009-03-06
Last Posted Date
2012-04-18
Lead Sponsor
AstraZeneca
Target Recruit Count
27
Registration Number
NCT00857584
Locations
🇪🇸

Research Site, Vitoria, Pais Vasco, Spain

Treatment Trial for Psychogenic Nonepileptic Seizures

First Posted Date
2009-02-03
Last Posted Date
2014-11-10
Lead Sponsor
Rhode Island Hospital
Target Recruit Count
38
Registration Number
NCT00835627
Locations
🇺🇸

University of Cincinnati, Cincinnati, Ohio, United States

🇺🇸

Stanford University, Stanford, California, United States

🇺🇸

Rhode Island Hospital, Providence, Rhode Island, United States

Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight

Phase 4
Completed
Conditions
Depression
Interventions
Drug: Sertraline
Drug: Metformin
First Posted Date
2009-02-03
Last Posted Date
2018-09-10
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
206
Registration Number
NCT00834652
Locations
🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

Postpartum Depression: Transdermal Estradiol Versus Sertraline

First Posted Date
2008-08-29
Last Posted Date
2019-09-10
Lead Sponsor
Northwestern University
Target Recruit Count
85
Registration Number
NCT00744328
Locations
🇺🇸

Northwestern University Feinberg School of Medicine; Asher Center for the Study and Treatment of Depressive Disorders, Chicago, Illinois, United States

Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury

Phase 2
Completed
Conditions
Traumatic Brain Injury
Interventions
Drug: Placebo
Drug: Sertraline
First Posted Date
2008-06-24
Last Posted Date
2015-08-25
Lead Sponsor
Baylor College of Medicine
Target Recruit Count
94
Registration Number
NCT00704379
Locations
🇺🇸

Baylor College of Medicine, Houston, Texas, United States

International Study to Predict Optimised Treatment - in Depression

First Posted Date
2008-06-09
Last Posted Date
2018-07-11
Lead Sponsor
BRC Operations Pty. Ltd.
Target Recruit Count
2688
Registration Number
NCT00693849
Locations
🇺🇸

Shanti Clinical Trials, Colton, California, United States

🇺🇸

A.D.D. Treatment Center, Mission Viejo, California, United States

🇺🇸

Veteran Affairs/Stanford University, Stanford, California, United States

and more 16 locations

A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder

Phase 4
Completed
Conditions
Panic Disorder
Interventions
Drug: Paroxetine
Drug: sertraline
First Posted Date
2008-05-14
Last Posted Date
2021-01-27
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
321
Registration Number
NCT00677352
Locations
🇯🇵

Pfizer Investigational Site, Minato-ku, Japan

A Study Comparing Duloxetine to Other Antidepressants in the Treatment of Severe Depression

First Posted Date
2008-04-25
Last Posted Date
2010-06-15
Lead Sponsor
Eli Lilly and Company
Target Recruit Count
750
Registration Number
NCT00666757
Locations
🇺🇸

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Brown Deer, Wisconsin, United States

Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans

First Posted Date
2008-04-09
Last Posted Date
2011-04-25
Lead Sponsor
University of Arkansas
Target Recruit Count
102
Registration Number
NCT00654953
Locations
🇺🇸

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Fluvoxamine and Sertraline in Childhood Autism - Does SSRI Therapy Improve Behaviour and/or Mood?

Phase 3
Completed
Conditions
Autism
Interventions
Drug: Placebo
Drug: fluvoxamine
Drug: sertraline
First Posted Date
2008-04-09
Last Posted Date
2008-04-09
Lead Sponsor
The Hospital for Sick Children
Target Recruit Count
108
Registration Number
NCT00655174
Locations
🇨🇦

The Hospital for Sick Children, Toronto, Ontario, Canada

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