Sertraline

Generic Name: Sertraline

Brand Names: Zoloft

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₇Cl_₂N

CAS Number: 79617-96-2

Unique Ingredient Identifier: QUC7NX6WMB

Background: Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as Citalopram and Fluoxetine. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects.
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Indication: Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety di...

Associated Conditions: Binge Eating Disorder (BED), Bulimia Nervosa, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Panic Disorder, Post Traumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder (SAD)

Associated Therapies: -

Clinical Trials

A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression

Phase 4

Completed

Conditions: Depressive Disorder, Major

Interventions: Drug: venlafaxine XR
Drug: sertraline

First Posted Date: 2008-03-27

Last Posted Date: 2021-01-27

Lead Sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Target Recruit Count: 163

Registration Number: NCT00644982

Locations: 🇹🇷
Pfizer Investigational Site, Malatya, Turkey

A Comparison of Sertraline-reboxetine Combination Therapy Versus Sertraline or Reboxetine Monotherapy in the Treatment of Major Depression.

Phase 2

Completed

Conditions: Depressive Disorder, Major

Interventions: Drug: sertraline/[S,S]-reboxetine
Drug: Placebo
Drug: [S,S]-reboxetine monotherapy
Drug: sertraline

First Posted Date: 2008-03-14

Last Posted Date: 2021-01-28

Lead Sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Target Recruit Count: 510

Registration Number: NCT00636246

Locations: 🇷🇺
Pfizer Investigational Site, Tomsk, Russian Federation

Treatment of Diabetes and Depression in Hispanics and African Americans and Its Effect on A1c and Quality of Life.

Phase 4

Completed

Conditions: Diabetes
Depression

Interventions: Drug: Placebo
Drug: sertraline

First Posted Date: 2008-02-26

Last Posted Date: 2017-12-12

Lead Sponsor: Charles Drew University of Medicine and Science

Target Recruit Count: 89

Registration Number: NCT00624013

Locations: 🇺🇸
Charles Drew University, Los Angeles, California, United States

Bioequivalency Study of Sertraline Under Fasting Conditions

Not Applicable

Completed

Conditions: Depression

First Posted Date: 2008-01-28

Last Posted Date: 2018-01-23

Lead Sponsor: Roxane Laboratories

Target Recruit Count: 38

Registration Number: NCT00602849

Locations: 🇨🇦
Anapharm Inc., Sainte-Fly, Quebec, Canada

Bioequivalency Study of Sertraline Under Fed Conditions

Not Applicable

Completed

Conditions: Depression

First Posted Date: 2008-01-28

Last Posted Date: 2018-01-23

Lead Sponsor: Roxane Laboratories

Target Recruit Count: 43

Registration Number: NCT00601588

Locations: 🇨🇦
Anapharm Inc., Sainte-Fly, Quebec, Canada

Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum Depression

Phase 2

Completed

Conditions: Depression, Postpartum

Interventions: Behavioral: Interpersonal psychotherapy (IPT)
Drug: Placebo
Drug: Sertraline
Behavioral: Clinical management
Behavioral: Mothercrafting

First Posted Date: 2008-01-28

Last Posted Date: 2016-09-21

Lead Sponsor: Women and Infants Hospital of Rhode Island

Target Recruit Count: 162

Registration Number: NCT00602355

Locations: 🇺🇸
Women and Infants Hospital, Providence, Rhode Island, United States
🇺🇸
University of Iowa, Iowa City, Iowa, United States

Dementia Antipsychotics And Antidepressants Discontinuation Study

Phase 4

Completed

Conditions: Dementia

Interventions: Drug: Risperidone
Drug: Escitalopram
Drug: Citalopram
Drug: Sertraline
Drug: Paroxetine

First Posted Date: 2008-01-15

Last Posted Date: 2011-02-23

Lead Sponsor: Sykehuset Innlandet HF

Target Recruit Count: 149

Registration Number: NCT00594269

Locations: 🇳🇴
Sykehuset Innlandet HF, Reinsvoll, Oppland, Norway
🇳🇴
Diakonihjemmets Hospital, Oslo, Norway
🇳🇴
Ullevaal University Hospital, Oslo, Norway

and more 5 locations

Vascular Effects of Sertraline in Heart Failure

Terminated

Conditions: Heart Failure
Depression

Interventions: Drug: sertraline

First Posted Date: 2008-01-03

Last Posted Date: 2009-07-23

Lead Sponsor: Yale University

Target Recruit Count: 4

Registration Number: NCT00585455

Locations: 🇺🇸
Yale University School of Medicine, New Haven, Connecticut, United States

Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder

Phase 4

Completed

Conditions: Premenstrual Dysphoric Disorder

Interventions: Drug: Sertraline
Drug: Placebo

First Posted Date: 2007-09-27

Last Posted Date: 2017-04-14

Lead Sponsor: Yale University

Target Recruit Count: 252

Registration Number: NCT00536198

Locations: 🇺🇸
Yale University School of Medicine, New Haven, Connecticut, United States
🇺🇸
Cornell University, Weill Medical College, New York, New York, United States
🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States

Maintenance Study for Adolescent Depression

Phase 4

Completed

Conditions: Depression

Interventions: Drug: placebo
Drug: Sertraline

First Posted Date: 2007-07-30

Last Posted Date: 2007-07-30

Lead Sponsor: Sunnybrook Health Sciences Centre

Target Recruit Count: 93

Registration Number: NCT00508859

Locations: 🇨🇦
UBC, Vancouver, British Columbia, Canada
🇨🇦
Dalhousie University, Halifax, Nova Scotia, Canada

Drug Development Updates

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