Vascular Effects of Sertraline in Heart Failure

Terminated

• Conditions: Heart Failure; Depression
• Interventions: Drug: sertraline

• Registration Number: NCT00585455
• Lead Sponsor: Yale University

Brief Summary

To determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and depression

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01
• Study First Submitted: 2007-12-22
• Study First Submitted QC: 2008-01-02
• Study First Posted: 2008-01-03
• Status Verified: 2009-07
• Primary Completion: 2009-07
• Study Completion: 2009-07
• Last Update Submitted: 2009-07-22
• Last Update Posted: 2009-07-23

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

• Chronic heart failure with LVEF<40%, age >21 years
• Depression requiring medical treatment with sertraline

Exclusion Criteria

• Known intolerance of sertraline

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
A	sertraline	Chronic heart failure patients with concomitant depression

Primary Outcome Measures

Name	Time	Method
Brachial artery flow-mediated dilation	2 months

Trial Locations

Locations (1)

Yale University School of Medicine; 🇺🇸 New Haven, Connecticut, United States