Sertraline

Generic Name: Sertraline

Brand Names: Zoloft

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₇Cl_₂N

CAS Number: 79617-96-2

Unique Ingredient Identifier: QUC7NX6WMB

Background: Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as Citalopram and Fluoxetine. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects.

Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.

Indication: Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.

Associated Conditions: Binge Eating Disorder (BED), Bulimia Nervosa, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Panic Disorder, Post Traumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder (SAD)

Clinical Trials

Effects of Sertraline on Brain Connectivity in Adolescents With OCD

Phase 1

Completed

Conditions: OCD

Interventions: Other: No Intervention
Drug: Sertraline

First Posted Date: 2016-06-13

Last Posted Date: 2021-01-05

Lead Sponsor: University of Minnesota

Target Recruit Count: 41

Registration Number: NCT02797808

Locations: 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States

Stress & Premenstrual Symptoms Study

Phase 4

Completed

Conditions: PMDD
Stress
Mood

Interventions: Drug: Sertraline

First Posted Date: 2016-05-19

Last Posted Date: 2022-11-17

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 84

Registration Number: NCT02777372

Locations: 🇺🇸
Center for Women's Reproductive Mental Health, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma

Phase 1

Completed

Conditions: Glioblastoma

Interventions: Drug: Temozolomide
Drug: Aprepitant
Drug: Minocycline
Drug: Disulfiram
Drug: Celecoxib
Drug: Sertraline
Drug: Captopril
Drug: Itraconazole
Drug: Ritonavir
Drug: Auranofin

First Posted Date: 2016-05-12

Last Posted Date: 2021-10-05

Lead Sponsor: University of Ulm

Target Recruit Count: 10

Registration Number: NCT02770378

Locations: 🇩🇪
University of Ulm School of Medicine, Ulm, Baden-Württemberg, Germany

A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity

Not Applicable

Completed

Conditions: Depression
Posttraumatic Stress Disorder
Mild Cognitive Impairment
Alcohol-Related Disorders
Substance-Related Disorders
Wounds and Injury
Suicidal Ideation
Brain Injuries
Quality of Life
Chronic Disease

Interventions: Behavioral: Motivational Interviewing
Behavioral: Cognitive Behavioral Therapy Elements
Behavioral: Care Management
Drug: Fluoxetine
Drug: Fluvoxamine
Drug: Paroxetine
Drug: Sertraline
Drug: Citalopram
Drug: Venlafaxine
Drug: Duloxetine
Drug: Mirtazapine
Drug: Diphenhydramine
Drug: Trazodone
Drug: Prazosin

First Posted Date: 2016-01-14

Last Posted Date: 2021-07-02

Lead Sponsor: University of Washington

Target Recruit Count: 635

Registration Number: NCT02655354

Locations: 🇺🇸
Jacobi Medical Center, Bronx, New York, United States
🇺🇸
University of Rochester, Rochester, New York, United States
🇺🇸
Honor Health, Scottsdale, Arizona, United States

and more 21 locations