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SN-38

Generic Name
SN-38
Brand Names
Trodelvy
Drug Type
Small Molecule
Chemical Formula
C22H20N2O5
CAS Number
86639-52-3
Unique Ingredient Identifier
0H43101T0J

Overview

7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan Irinotecan, a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.

Indication

Investigated for use/treatment in colorectal cancer.

Associated Conditions

  • Hormone Receptor Positive Metastatic Breast Cancer
  • Locally Advanced or Metastatic Urothelial Carcinoma (UC)
  • Metastatic Triple Negative Breast Cancers
  • Unresectable Triple-Negative Breast Carcinoma
  • Metastatic HR Positive, HER2/Neu Negative Breast Cancer
  • Unresectable Locally Advanced Triple-negative Breast Cancer
  • Unresectable, locally advanced HR Positive, HER2/Neu Negative Breast Cancer
  • Unresectable, locally advanced Hormone Receptor Positive Breast Carcinoma

Clinical Trials

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Title
Posted
Study ID
Phase
Status
Sponsor
2025/03/03
Phase 1/2
Not yet recruiting
2023/05/03
Phase 3
Active, not recruiting
2023/05/01
Phase 2
Recruiting
2023/04/27
Phase 1
Recruiting
Shilpa Gupta, MD
2023/03/15
Phase 2
Recruiting
2023/01/09
Phase 2
Recruiting
2022/11/08
Phase 3
Recruiting
2022/10/14
Phase 2
Recruiting
2022/09/23
Phase 3
Recruiting
2022/08/30
Phase 2
Active, not recruiting
MedSIR

FDA Drug Approvals

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EMA Drug Approvals

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HSA Drug Approvals

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NMPA Drug Approvals

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PPB Drug Approvals

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TGA Drug Approvals

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