Sugammadex
- Generic Name
- Sugammadex
- Brand Names
- Bridion, Sugammadex Adroiq, Sugammadex Amomed, Sugammadex Fresenius Kabi, Sugammadex Mylan, Sugammadex Piramal
- Drug Type
- Small Molecule
- Chemical Formula
- C72H112O48S8
- CAS Number
- 343306-71-8
- Unique Ingredient Identifier
- 361LPM2T56
- Background
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
- Indication
Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide in adults and pediatric patients ≥2 years old who are undergoing surgery.
- Associated Conditions
- Neuromuscular blockade caused by vecuronium bromide
Comparison of Time to Extubation Using Sugammadex or Neostigmine
- Conditions
- Neuromuscular BlockadeChronic Obstructive Pulmonary Disease
- Interventions
- Drug: neostigmine/glycopyrrolate
- First Posted Date
- 2020-10-28
- Last Posted Date
- 2024-03-13
- Lead Sponsor
- Temple University
- Target Recruit Count
- 58
- Registration Number
- NCT04606901
- Locations
- 🇺🇸
Temple University Hospital, Philadelphia, Pennsylvania, United States
Optimizing Post-operative Recovery in Bariatric Patients With Obstructive Sleep Apnea Undergoing Outpatient Surgery: A Comparison of Sugammadex and Neostigmine
- First Posted Date
- 2020-09-30
- Last Posted Date
- 2024-04-15
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 90
- Registration Number
- NCT04570150
- Locations
- 🇺🇸
University of California San Diego, La Jolla, California, United States
Effectiveness of Sugammadex on Muscle Relaxant Reversal in Preterm Neonates
- First Posted Date
- 2020-09-28
- Last Posted Date
- 2020-09-28
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 60
- Registration Number
- NCT04566796
- Locations
- 🇪🇬
Alexandria university, Alexandria, Egypt
A Pharmacokinetic Study of Sugammadex in Dialysis Patients
- First Posted Date
- 2020-09-21
- Last Posted Date
- 2021-09-17
- Lead Sponsor
- Tetsuro Sakai
- Registration Number
- NCT04556721
- Locations
- 🇺🇸
UPMC Montefiore Hospital, Pittsburgh, Pennsylvania, United States
Sugammadex To IMprove Bowel Function
- Conditions
- Bowel DysfunctionPostoperative ComplicationsNeuromuscular Blockade
- Interventions
- First Posted Date
- 2020-09-14
- Last Posted Date
- 2024-07-29
- Lead Sponsor
- Oregon Health and Science University
- Target Recruit Count
- 120
- Registration Number
- NCT04546672
- Locations
- 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States
Comparison of the Impacts of Sugammadex With Neostigmine on Patency of Laryngeal Opening (Glottic Aperture Angle)
- Conditions
- Supraglottic Airway Device Insertion
- Interventions
- First Posted Date
- 2020-09-10
- Last Posted Date
- 2020-09-10
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 84
- Registration Number
- NCT04545099
The Effect of Sugammadex During Transcranial Electrical Motor Evoked Potential Monitoring in Spinal Surgery
- First Posted Date
- 2020-07-15
- Last Posted Date
- 2021-04-06
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 66
- Registration Number
- NCT04471376
- Locations
- 🇨🇳
Beijing Tiantan Hospital, Beijing, China
Sugammadex on Remifentanil Ce for Preventing Emergence Cough in Female
- Conditions
- Gallbladder Diseases
- Interventions
- First Posted Date
- 2020-05-29
- Last Posted Date
- 2021-01-08
- Lead Sponsor
- Ajou University School of Medicine
- Target Recruit Count
- 40
- Registration Number
- NCT04407078
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Gyeonggido, Korea, Republic of
Pharmacokinetic-pharmacodynamic Analysis of Sugammadex for Conventional Reversal in Children
- Conditions
- Anesthesia, GeneralNeuromuscular Blockade
- Interventions
- Drug: Neuromuscular reversal agent injection
- First Posted Date
- 2020-04-15
- Last Posted Date
- 2022-02-10
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 32
- Registration Number
- NCT04347486
- Locations
- 🇰🇷
SNUH, Seoul, Jongro Gu, Korea, Republic of
Comparison of QoR-15 in Laparoscopic Cholecystectomy: Sugammadex vs. Neostigmine
- Conditions
- Neuromuscular Blockade Reversal AgentSugammadexQuality of RecoveryLaparoscopic CholecystectomyNeostigmine
- Interventions
- First Posted Date
- 2020-04-02
- Last Posted Date
- 2020-12-24
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 77
- Registration Number
- NCT04332627
- Locations
- 🇰🇷
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.