Sugammadex
- Generic Name
- Sugammadex
- Brand Names
- Bridion, Sugammadex Adroiq, Sugammadex Amomed, Sugammadex Fresenius Kabi, Sugammadex Mylan, Sugammadex Piramal
- Drug Type
- Small Molecule
- Chemical Formula
- C72H112O48S8
- CAS Number
- 343306-71-8
- Unique Ingredient Identifier
- 361LPM2T56
- Background
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
- Indication
Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide in adults and pediatric patients ≥2 years old who are undergoing surgery.
- Associated Conditions
- Neuromuscular blockade caused by vecuronium bromide
Efficacy, Safety, and Pharmacokinetics of Sugammadex (MK-8616) for Reversal of Neuromuscular Blockade in Pediatric Participants Aged Birth to <2 Years (MK-8616-169)
- Conditions
- Neuromuscular Blockade
- Interventions
- First Posted Date
- 2019-04-09
- Last Posted Date
- 2023-10-02
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 137
- Registration Number
- NCT03909165
- Locations
- 🇳🇱
University Medical Center Groningen ( Site 4227), Groningen, Netherlands
🇳🇱Wilhelmina Kinderziekenhuis ( Site 4228), Utrecht, Netherlands
🇺🇸Variety Children's Hospital D.B.A. Nicklaus Children's Hospital ( Site 3019), Miami, Florida, United States
Deep Neuromuscular Relaxation Optimizing Low-Pressure Bariatric Surgery
- Conditions
- Bariatric Surgery
- Interventions
- Procedure: Deep Neuromuscular Blockade
- First Posted Date
- 2019-01-15
- Last Posted Date
- 2019-01-15
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 100
- Registration Number
- NCT03803982
Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children
- Conditions
- Anesthetics, InhalationNeuromuscular BlockadeAnesthesia, General
- Interventions
- First Posted Date
- 2019-01-07
- Last Posted Date
- 2021-05-04
- Lead Sponsor
- Istanbul University
- Target Recruit Count
- 148
- Registration Number
- NCT03795259
- Locations
- 🇹🇷
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Please Select, Turkey
The Use of Sugammadex in the Critically Ill
- Conditions
- Critical Illness
- Interventions
- First Posted Date
- 2019-01-03
- Last Posted Date
- 2019-08-21
- Lead Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Target Recruit Count
- 50
- Registration Number
- NCT03791801
- Locations
- 🇨🇦
McGill University Health Center, Montreal, Quebec, Canada
🇨🇦MUHC, Montréal, Quebec, Canada
the Efficacy and Safety of Sugammadex in Children 0-2 Years Old
- Conditions
- Hepatic MetastasesAnesthesiaPediatric TumorPediatric CancerPediatric HepatoblastomaBeta-Thalassemia
- Interventions
- First Posted Date
- 2018-11-02
- Last Posted Date
- 2018-11-02
- Target Recruit Count
- 62
- Registration Number
- NCT03728543
- Locations
- 🇷🇺
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
Adequate Dosage of Sugammadex on Thyroid Surgery
- Conditions
- Thyroid Surgery
- Interventions
- First Posted Date
- 2018-09-28
- Last Posted Date
- 2020-06-11
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 102
- Registration Number
- NCT03689413
- Locations
- 🇰🇷
Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea, Republic of
Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
- Conditions
- Obstructive Sleep Apnea
- Interventions
- First Posted Date
- 2018-09-20
- Last Posted Date
- 2025-03-20
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 120
- Registration Number
- NCT03679611
- Locations
- 🇨🇦
Toronto Western Hospital, Toronto, Ontario, Canada
Reversal of Residual Neuromuscular Blockade at Train-of-four Ratio 0.3 With Sugammadex and Neostigmine
- Conditions
- Neuromuscular Blockade
- Interventions
- First Posted Date
- 2018-09-04
- Last Posted Date
- 2020-08-11
- Lead Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
- Target Recruit Count
- 121
- Registration Number
- NCT03656614
- Locations
- 🇨🇳
Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou, Guangdong, China
The Effect of Sugammadex on the Outcome After Colorectal Cancer Surgery
- First Posted Date
- 2018-08-08
- Last Posted Date
- 2019-08-20
- Lead Sponsor
- Ajou University School of Medicine
- Target Recruit Count
- 585
- Registration Number
- NCT03619759
- Locations
- 🇰🇷
Ajou university school of medicine, Suwon, Gyeonggi-do, Korea, Republic of
Sugammadex on Remifentanil Ce for Preventing Emergence Cough in Male
- Conditions
- Gallbladder Diseases
- Interventions
- First Posted Date
- 2018-07-11
- Last Posted Date
- 2020-05-29
- Lead Sponsor
- Ajou University School of Medicine
- Target Recruit Count
- 42
- Registration Number
- NCT03583021
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Seoul, Korea, Republic of
Drug Development Updates
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