Imiquimod

Generic Name: Imiquimod

Brand Names: Aldara, Vyloma, Zyclara

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₁₆N_₄

CAS Number: 99011-02-6

Unique Ingredient Identifier: P1QW714R7M

Background: Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that cause warts directly, however, it does help to relieve and control wart production. Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma.

Indication: For the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in immunocompetent adults. Also indicated for the treatment of external genital and perianal warts/condyloma acuminata in individuals 12 years old and above.

Associated Conditions: Actinic Keratoses of the face, Actinic Keratoses of the scalp, Condylomata Acuminata, Herpes Simplex Infections, Molluscum Contagiosum, Superficial Basal Cell Carcinoma

Associated Therapies: -

Clinical Trials

Imiquimod Plus Antimony Immunochemotherapy for Cutaneous Leishmaniasis

Phase 3

Completed

Conditions: Cutaneous Leishmaniasis

First Posted Date: 2005-11-23

Last Posted Date: 2008-06-12

Lead Sponsor: Drugs for Neglected Diseases

Target Recruit Count: 80

Registration Number: NCT00257530

Locations: 🇵🇪
UPCH, Cusco, Peru
🇵🇪
IMT Alexander Von Humboldt, Lima, Peru

Safety and Efficacy Study of Imiquimod 5% Cream Applied 3x Per Week for 8 or 12 Weeks in Low Risk Nodular Basal Cell Carcinoma

Phase 4

Completed

Conditions: Carcinoma, Basal Cell

First Posted Date: 2005-09-20

Last Posted Date: 2011-09-01

Lead Sponsor: University Hospital Tuebingen

Target Recruit Count: 100

Registration Number: NCT00204555

Locations: 🇩🇪
Skin Cancer Program, Department of Dermatology, Liebermeisterstrasse 8, Tübingen, BW, Germany

Aldara for the Treatment of Large and/or Multiple sBCC

Phase 3

Completed

Conditions: Carcinoma, Basal Cell

Interventions: Drug: Imiquimod

First Posted Date: 2005-09-19

Last Posted Date: 2022-02-22

Lead Sponsor: MEDA Pharma GmbH & Co. KG

Target Recruit Count: 111

Registration Number: NCT00189280

Locations: 🇫🇷
Service de DermatologieHôpital Dupuytren, Limoges, France

A Study to Evaluate Effectiveness of Imiquimod 5% Cream in Superficial Basal Cell Carcinoma

Phase 3

Completed

Conditions: Basal Cell Carcinoma

First Posted Date: 2005-09-19

Last Posted Date: 2022-02-07

Lead Sponsor: MEDA Pharma GmbH & Co. KG

Target Recruit Count: 160

Registration Number: NCT00189241

Locations: 🇩🇪
Univertätsklinik für Dermatologie und Venerologie, Magedeburg, Germany

A Study to Follow up Recurrence Rates of Actinic Keratoses One Year After Completion of Study 1487-IMIQ

Completed

Conditions: Actinic Keratoses

Interventions: Drug: Imiquimod

First Posted Date: 2005-09-19

Last Posted Date: 2022-02-07

Lead Sponsor: MEDA Pharma GmbH & Co. KG

Target Recruit Count: 72

Registration Number: NCT00189254

Study of Imiquimod Cream Prior to Ablative Therapy in External Ano-Genital Warts

Phase 4

Completed

Conditions: Genital Warts

Interventions: Drug: Imiquimod
Other: vehicle cream

First Posted Date: 2005-09-19

Last Posted Date: 2022-02-07

Lead Sponsor: MEDA Pharma GmbH & Co. KG

Target Recruit Count: 128

Registration Number: NCT00189293

Locations: 🇮🇹
Unità Operativa di Ginecologia Oncologica, RCCS Ospedale Oncologico, Bari, Italy
🇮🇹
Servizio Autonomo di Diagnosi Precoce dei Tumori Ginecologici Ospedale Vittorio Emanuele, Catania, Italy
🇮🇹
Clinica Ostetrica Ginecologica, Ospedale Careggi, Firenze, Italy

and more 9 locations