Adavosertib

Generic Name
Adavosertib
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C27H32N8O2
CAS Number
955365-80-7
Unique Ingredient Identifier
K2T6HJX3I3
Background

MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.

Associated Conditions
-
Associated Therapies
-

Phase Ib Study AZD1775 in Combination With Carboplatin and Paclitaxel in Adult Asian Patients With Solid Tumours

First Posted Date
2015-01-19
Last Posted Date
2019-03-25
Lead Sponsor
AstraZeneca
Target Recruit Count
19
Registration Number
NCT02341456
Locations
🇰🇷

Research Site, Seoul, Korea, Republic of

Adavosertib Plus Chemotherapy in Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

First Posted Date
2014-10-23
Last Posted Date
2023-10-03
Lead Sponsor
AstraZeneca
Target Recruit Count
95
Registration Number
NCT02272790
Locations
🇳🇱

Research Site, Amsterdam, Netherlands

Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Gemcitabine Hydrochloride With or Without WEE1 Inhibitor AZD1775 in Treating Patients With Previously Untreated Pancreatic Cancer That Is Metastatic or Cannot Be Removed by Surgery

First Posted Date
2014-07-18
Last Posted Date
2023-04-25
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
8
Registration Number
NCT02194829
Locations
🇺🇸

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, United States

🇺🇸

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

🇺🇸

University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania, United States

and more 2 locations

Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

First Posted Date
2014-04-02
Last Posted Date
2024-07-24
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
124
Registration Number
NCT02101775
Locations
🇨🇦

University Health Network Princess Margaret Cancer Center P2C, Toronto, Ontario, Canada

🇺🇸

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States

🇨🇦

BCCA-Cancer Centre for the Southern Interior, Kelowna, British Columbia, Canada

and more 13 locations

Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors

First Posted Date
2014-03-24
Last Posted Date
2023-09-26
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
76
Registration Number
NCT02095132
Locations
🇺🇸

C S Mott Children's Hospital, Ann Arbor, Michigan, United States

🇺🇸

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York, United States

🇺🇸

Children's Hospital of Wisconsin, Milwaukee, Wisconsin, United States

and more 21 locations

Ph II Trial of Carboplatin and Pemetrexed With or Without AZD1775 for Untreated Lung Cancer

First Posted Date
2014-03-14
Last Posted Date
2017-03-29
Lead Sponsor
AstraZeneca
Target Recruit Count
22
Registration Number
NCT02087241
Locations
🇺🇸

Research Site, Nashville, Tennessee, United States

A Placebo Controlled Study Comparing AZD1775+ Docetaxel Versus Placebo+Docetaxel to Treat Lung Cancer

First Posted Date
2014-03-14
Last Posted Date
2016-06-14
Lead Sponsor
AstraZeneca
Target Recruit Count
48
Registration Number
NCT02087176
Locations
🇺🇸

Research Site, Milwaukee, Wisconsin, United States

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

First Posted Date
2013-08-14
Last Posted Date
2024-01-31
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
46
Registration Number
NCT01922076
Locations
🇺🇸

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States

🇺🇸

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas, United States

🇺🇸

Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia, United States

and more 21 locations

Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma

First Posted Date
2013-05-08
Last Posted Date
2024-07-03
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
74
Registration Number
NCT01849146
Locations
🇺🇸

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California, United States

🇺🇸

Cleveland Clinic Foundation, Cleveland, Ohio, United States

🇺🇸

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States

and more 9 locations
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