Overview
Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Background
Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Indication
For the treatment of osteoarthritis affecting the hip or knee .
Associated Conditions
- Osteoarthritis in the Hip Joint
- Osteoarthritis of the Knee
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/04/04 | Phase 2 | Completed | |||
2024/03/13 | Phase 1 | Not yet recruiting | International Bio service | ||
2022/02/07 | Phase 2 | UNKNOWN | University of Campinas, Brazil | ||
2020/04/17 | N/A | Completed | |||
2018/03/22 | Phase 1 | Completed | Castle Creek Pharmaceuticals, LLC | ||
2018/03/22 | Phase 1 | Completed | Castle Creek Pharmaceuticals, LLC | ||
2018/03/21 | Phase 1 | Completed | Castle Creek Pharmaceuticals, LLC | ||
2018/03/21 | Phase 1 | Completed | Castle Creek Pharmaceuticals, LLC | ||
2018/03/21 | Phase 1 | Completed | Castle Creek Pharmaceuticals, LLC | ||
2018/01/19 | Phase 4 | UNKNOWN | Whan-Seok Choi |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Diacerein Capsules | 国药准字H20244889 | 化学药品 | 胶囊剂 | 9/10/2024 | |
| Diacerein Capsules | 国药准字H20243806 | 化学药品 | 胶囊剂 | 5/28/2024 | |
| Diacerein Capsules | 国药准字H20233671 | 化学药品 | 胶囊剂 | 6/7/2023 | |
| Diacerein Capsules | 国药准字HJ20150131 | 化学药品 | 胶囊剂 | 10/12/2020 | |
| Diacerein Capsules | 国药准字HJ20150130 | 化学药品 | 胶囊剂 | 10/12/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| ARTRODAR CAP 50MG | N/A | N/A | N/A | 12/31/2007 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||