Chlorambucil

Generic Name
Chlorambucil
Brand Names
Leukeran
Drug Type
Small Molecule
Chemical Formula
C14H19Cl2NO2
CAS Number
305-03-3
Unique Ingredient Identifier
18D0SL7309
Background

A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)

Indication

For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia.

Associated Conditions
Chronic Lymphocytic Leukemia, Hodgkins Disease (HD), Indolent Lymphoma, Lymphoma, Lymphoma, Diffuse, MALT Lymphoma, Mantle Cell Lymphoma (MCL), Nephrotic syndrome with lesion of minimal change glomerulonephritis, Non-Hodgkin's Lymphoma (NHL), Waldenström's Macroglobulinemia (WM), Giant follicular lymphoma
Associated Therapies
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