Chlorambucil
- Generic Name
- Chlorambucil
- Brand Names
- Leukeran
- Drug Type
- Small Molecule
- Chemical Formula
- C14H19Cl2NO2
- CAS Number
- 305-03-3
- Unique Ingredient Identifier
- 18D0SL7309
Overview
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Background
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Indication
For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia.
Associated Conditions
- Chronic Lymphocytic Leukemia
- Hodgkins Disease (HD)
- Indolent Lymphoma
- Lymphoma
- Lymphoma, Diffuse
- MALT Lymphoma
- Mantle Cell Lymphoma (MCL)
- Nephrotic syndrome with lesion of minimal change glomerulonephritis
- Non-Hodgkin's Lymphoma (NHL)
- Waldenström's Macroglobulinemia (WM)
- Giant follicular lymphoma
Clinical Trials
FDA Approved Products
Singapore Approved Products
Drug Development Updates
Stay informed with timely notifications on clinical trials and research advancements.