Niclosamide

Generic Name
Niclosamide
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C13H8Cl2N2O4
CAS Number
50-65-7
Unique Ingredient Identifier
8KK8CQ2K8G
Background

Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an eve...

Indication

For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis.

Associated Conditions
Helminthic infection, Tapeworm infestation
Associated Therapies
-

Niclosamide in Pediatric Patients With Relapsed and Refractory AML

Phase 1
Recruiting
Conditions
Interventions
First Posted Date
2022-01-12
Last Posted Date
2024-01-11
Lead Sponsor
Stanford University
Target Recruit Count
16
Registration Number
NCT05188170
Locations
🇺🇸

Stanford University, Palo Alto, California, United States

Safety and Efficacy of Intranasal Administration of Niclosamide (UNI91103) in Adults With Asymptomatic or Mild COVID-19

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2021-06-21
Last Posted Date
2022-02-21
Lead Sponsor
UNION therapeutics
Target Recruit Count
4
Registration Number
NCT04932915
Locations
🇩🇪

Klinische Forschung Dresden GmbH, Dresden, Germany

🇩🇪

Klinische Forschung Berlin-Mitte GmbH, Berlin, Germany

🇩🇪

Klinische Forschung Hamburg GmbH, Hamburg, Germany

PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V

First Posted Date
2021-05-03
Last Posted Date
2024-03-22
Lead Sponsor
Cambridge University Hospitals NHS Foundation Trust
Target Recruit Count
5000
Registration Number
NCT04870333
Locations
🇬🇧

Queen Elizabeth Hospital, King's Lynn, NHS Foundation Trust, King's Lynn, United Kingdom

🇬🇧

University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

🇬🇧

Imperial College Healthcare NHS Trust, London, United Kingdom

and more 42 locations

Safety and Efficacy of Niclosamide in Patients With COVID-19 With Gastrointestinal Infection

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2021-04-26
Last Posted Date
2024-10-08
Lead Sponsor
Entero Therapeutics
Target Recruit Count
166
Registration Number
NCT04858425
Locations
🇮🇳

Yashoda Hospital, Secunderabad, Andhra Pradesh, India

🇮🇳

SSG Hospital and Medical Institute, Vadodara, Gujarat, India

🇺🇦

Municipal Non-profit Enterprise "City Clinical Hospital # 4" of Dnipro City Council, Dnipro, Ukraine

and more 22 locations

A Single and Multiple Ascending Dose Study of Niclosamide in Healthy Volunteers

Phase 1
Completed
Conditions
Interventions
First Posted Date
2021-01-12
Last Posted Date
2023-12-08
Lead Sponsor
NeuroBo Pharmaceuticals Inc.
Target Recruit Count
66
Registration Number
NCT04705415
Locations
🇺🇸

WCCT Global Inc., Cypress, California, United States

Safety and Pharmacokinetics of a Novel Niclosamide Solution in Combination With Camostat

Phase 1
Completed
Conditions
Interventions
First Posted Date
2020-11-25
Last Posted Date
2021-11-29
Lead Sponsor
Charité Research Organisation GmbH
Target Recruit Count
28
Registration Number
NCT04644705
Locations
🇩🇪

Charité Research Organisation GmbH, Berlin, Germany

Study of Niclosamide in Moderate and Severe Hospitalized Coronavirus-19 (COVID-19) Patients

Phase 2
Completed
Conditions
Interventions
First Posted Date
2020-10-27
Last Posted Date
2023-12-08
Lead Sponsor
NeuroBo Pharmaceuticals Inc.
Target Recruit Count
120
Registration Number
NCT04603924
Locations
🇺🇸

Baptist Health Research Institute, Jacksonville, Florida, United States

🇺🇸

University of California, Irvine, Irvine, California, United States

🇺🇸

AdventHealth Tampa, Tampa, Florida, United States

and more 5 locations

Niclosamide for Mild to Moderate COVID-19

First Posted Date
2020-05-22
Last Posted Date
2022-04-12
Lead Sponsor
Tufts Medical Center
Target Recruit Count
73
Registration Number
NCT04399356
Locations
🇺🇸

Tufts Medical Center, Boston, Massachusetts, United States

Niclosamide Role in Diabetic Nephropathy

First Posted Date
2020-03-23
Last Posted Date
2022-10-20
Lead Sponsor
Tanta University
Target Recruit Count
60
Registration Number
NCT04317430
Locations
🇪🇬

Faculty of Pharmacy, Tanta University, Tanta, Egypt

Niclosamide for Familial Adenomatous Polyposis

First Posted Date
2020-03-05
Last Posted Date
2020-03-05
Lead Sponsor
Yonsei University
Target Recruit Count
72
Registration Number
NCT04296851
Locations
🇰🇷

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

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