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Bismuth subsalicylate

Generic Name
Bismuth subsalicylate
Brand Names
Diphen, Kaopectate Reformulated Aug 2006, Kola-pectin, Pepto-bismol, Percy Medicine
Drug Type
Small Molecule
Chemical Formula
C7H5BiO4
CAS Number
14882-18-9
Unique Ingredient Identifier
62TEY51RR1

Overview

Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of salicylic acid linked to trivalent bismuth cation. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth subsalicylate has been around for over 100 years: it was originally developed in 1901 for hygienic use and sanitation for cholera infection. Bismuth subsalicylate was first approved by the FDA in 1939 and is now mainly used to relieve nausea, diarrhea, and gastrointestinal discomfort. It is an active ingredient found in Pepto-Bismol, a common over-the-counter medication that is used to temporarily treat discomforts of the stomach and gastrointestinal tract. Bismuth subsalicylate is a component of HELIDAC Therapy (bismuth subsalicylate, metronidazole, and tetracycline), which is a treatment regimen indicated for the eradication of H. pylori for treatment of patients with H. pylori infection and duodenal ulcer disease.

Background

Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of salicylic acid linked to trivalent bismuth cation. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth subsalicylate has been around for over 100 years: it was originally developed in 1901 for hygienic use and sanitation for cholera infection. Bismuth subsalicylate was first approved by the FDA in 1939 and is now mainly used to relieve nausea, diarrhea, and gastrointestinal discomfort. It is an active ingredient found in Pepto-Bismol, a common over-the-counter medication that is used to temporarily treat discomforts of the stomach and gastrointestinal tract. Bismuth subsalicylate is a component of HELIDAC Therapy (bismuth subsalicylate, metronidazole, and tetracycline), which is a treatment regimen indicated for the eradication of H. pylori for treatment of patients with H. pylori infection and duodenal ulcer disease.

Indication

Bismuth subsalicylate is indicated to temporarily relieve diarrhea, travelers' diarrhea, and upset stomach due to overindulgence in food and drink, including heartburn, indigestion, nausea, gas, belching, and fullness. Bismuth subsalicylate is a component of HELIDAC Therapy (bismuth subsalicylate, metronidazole, and tetracycline), which is a treatment regimen indicated for the eradication of H. pylori for treatment of patients with H. pylori infection and duodenal ulcer disease.

Associated Conditions

  • Diarrhea
  • Dyspepsia
  • Flatulence
  • Heartburn
  • Helicobacter Pylori Infection
  • Nausea
  • Traveler's Diarrhea
  • Upset stomach
  • Belching
  • Gastrointestinal fullness

FDA Approved Products

Kaopectate
Manufacturer:Kramer Laboratories
Route:ORAL
Strength:262 mg in 1 1
Approved: 2025/04/17
NDC:55505-206
Kaopectate Vanilla Flavor Anti Diarrheal
Manufacturer:Kramer Laboratories
Route:ORAL
Strength:262 mg in 15 mL
Approved: 2025/04/17
NDC:55505-198
Kaopectate
Manufacturer:Kramer Laboratories
Route:ORAL
Strength:262 mg in 1 1
Approved: 2025/04/17
NDC:55505-197
Stomach Relief Regular Strength
Manufacturer:ATLANTIC BIOLOGICALS CORP.
Route:ORAL
Strength:525 mg in 30 mL
Approved: 2025/05/12
NDC:17856-1286
Soothe
Manufacturer:Walgreens
Route:ORAL
Strength:525 mg in 30 mL
Approved: 2025/05/07
NDC:0363-0025

Singapore Approved Products

No Singapore products found for this drug

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