Overview
Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa). Preotact is used in the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic fractures and is marketed in Europe by Nycomed. Preos is a registered trade mark owned by NPS Pharmaceuticals, Inc. The name Preos and the New Drug Application is pending approval by the U.S. Food and Drug Administration (FDA).
Indication
For use/treatment in osteoporosis.
Associated Conditions
- Hypocalcemia
- Hypoparathyroidism
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2005/09/15 | Phase 2 | Completed | |||
2005/09/15 | Phase 3 | Completed | |||
2005/09/05 | Phase 1 | Terminated | |||
2000/12/18 | Phase 1 | Completed | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | ||
2000/03/27 | Phase 2 | Completed | |||
2000/03/27 | Phase 2 | Completed | Dennis Black | ||
2000/01/19 | Phase 3 | Completed | |||
1999/10/19 | Not Applicable | Completed |
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