Tenofovir alafenamide
- Generic Name
- Tenofovir alafenamide
- Brand Names
- Biktarvy, Descovy, Genvoya, Odefsey, Vemlidy
- Drug Type
- Small Molecule
- Chemical Formula
- C21H29N6O5P
- CAS Number
- 379270-37-8
- Unique Ingredient Identifier
- EL9943AG5J
- Background
Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal diffusion. Tenofov...
- Indication
Tenofovir alafenamide is indicated for the treatment of hepatitis B virus infection in adults and pediatric patients 12 years of age and older with compensated liver disease.
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- Associated Conditions
- Chronic Hepatitis B Infection, Human Immunodeficiency Virus Type 1 (HIV-1) Infection
- Associated Therapies
- Pre-Exposure Prophylaxis (PrEP)
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