Dapagliflozin

Generic Name
Dapagliflozin
Brand Names
Edistride, Farxiga, Forxiga, Qtern, Qternmet, Xigduo, Dapagliflozin Viatris
Drug Type
Small Molecule
Chemical Formula
C21H25ClO6
CAS Number
461432-26-8
Unique Ingredient Identifier
1ULL0QJ8UC
Background

Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tubule of the nephron and causing glycosuria. Dapagliflozin has been investigated either as monotherapy or as an adjunct treatment with insulin or other oral hypoglycemic agents.

Dapagliflozin was originally approved by the FDA on Jan 08, 2014, to improve glycemic control in adults with type 2 diabetes in conjunction with diet and exercise. It was later approved to reduce the risk of kidney function decline, kidney failure, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease in April 2021.

Indication

Dapagliflozin is indicated as an adjunct treatment to improve glycemic control in adult patients with type 2 diabetes mellitus along with diet and exercise.For patients with chronic kidney disease at risk of progression, dapagliflozin in used to reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, and

hospitalization for heart failure. Dapagliflozin is also indicated to either reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure or reduce the risk of hospitalization for heart failure in adults with type 2 diabetes mellitus and either established cardiovascular disease or multiple cardiovascular risk factors. Combination products with dapagliflozin also exist, either as a dapagliflozin-saxagliptin or dapagliflozin-metformin hydrochloride formulation. Both are used as an adjunct treatment to diet and exercise to improve glycemic control in adults with type 2 diabetes.

Associated Conditions
Cardiovascular Mortality, End Stage Renal Disease (ESRD), Hospitalizations, Type 2 Diabetes Mellitus, Decreased estimated glomerular filtration rate, Hospitalization due to cardiac failure
Associated Therapies
-

Treating to Reduce Albuminuria and Normalize Hemodynamic Function in Focal ScLerosis With dApagliflozin Trial Effects

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-10-23
Last Posted Date
2018-01-16
Lead Sponsor
University Health Network, Toronto
Target Recruit Count
10
Registration Number
NCT02585804
Locations
🇨🇦

Renal Physiology Laboratory, University Health Network, Toronto, Ontario, Canada

Dapagliflozin on Hyperlipidemia and Insulin Resistance in Type 2 Diabetic Patients (DAPHNIS Study)

Phase 4
Conditions
Interventions
First Posted Date
2015-10-16
Last Posted Date
2018-08-29
Lead Sponsor
Osaka University
Target Recruit Count
50
Registration Number
NCT02577159
Locations
🇯🇵

Sousei Hospital, Kadoma, Osaka, Japan

🇯🇵

Osaka University Hospital, Suita, Osaka, Japan

🇯🇵

Osaka Central Hospital, Osaka city, Osaka, Japan

Foxiga Korea Local Phase 4 Study

First Posted Date
2015-10-01
Last Posted Date
2019-08-20
Lead Sponsor
AstraZeneca
Target Recruit Count
125
Registration Number
NCT02564926
Locations
🇰🇷

Research Site, Wonju-si, Korea, Republic of

Effects of SGLT-2 Inhibition on Hepatic Glucose and Energy Metabolism

First Posted Date
2015-09-23
Last Posted Date
2016-09-27
Lead Sponsor
Medical University of Vienna
Target Recruit Count
20
Registration Number
NCT02558270
Locations
🇦🇹

Medical University Of Vienna, Department of Internal Medicine III, Vienna, Austria

Does Dapagliflozin Promote Favorable Health Benefits That Are Independent Of Weight Loss?

First Posted Date
2015-08-13
Last Posted Date
2019-01-03
Lead Sponsor
Christopher Bell
Target Recruit Count
9
Registration Number
NCT02520518
Locations
🇺🇸

Colorado State University, Dept. of Health and Exercise Science, Fort Collins, Colorado, United States

Dapagliflozin As Additional Treatment To Liraglutide And Insulin In Patients With Type 1 Diabetes

First Posted Date
2015-08-10
Last Posted Date
2024-01-24
Lead Sponsor
University at Buffalo
Target Recruit Count
26
Registration Number
NCT02518945
Locations
🇺🇸

ECMC Ambulatory Center, 3rd Floor, Buffalo, New York, United States

Effect of Dapagliflozine on Systemic and Renal Endothelial Function

First Posted Date
2015-07-17
Last Posted Date
2015-07-17
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
22
Registration Number
NCT02501616
Locations
🇰🇷

Boramae medical center, Seoul, Korea, Republic of

Vildagliptin Versus Dapagliflozin on Glucagon

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-06-18
Last Posted Date
2019-05-02
Lead Sponsor
Lund University
Target Recruit Count
28
Registration Number
NCT02475070
Locations
🇸🇪

Lund University, Lund, Sweden

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