MedPath

Yttrium Y-90

Generic Name
Yttrium Y-90
Brand Names
Yttriga
Drug Type
Small Molecule
Chemical Formula
Y
CAS Number
10098-91-6
Unique Ingredient Identifier
1K8M7UR6O1
Background

Yttrium 90 has been investigated for the treatment of Colon Cancer and Colorectal Cancer.

Associated Conditions
Radiollabeling

Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant

Phase 1
Recruiting
Conditions
Hepatocellular Carcinoma (HCC)
Macrovascular Invasion
Liver Transplant Surgery
Downstaging
Interventions
Radiation: Stereotactic body radiotherapy (SBRT)
First Posted Date
2024-12-10
Last Posted Date
2024-12-16
Lead Sponsor
University Health Network, Toronto
Target Recruit Count
48
Registration Number
NCT06725121
Locations
🇨🇦

London Health Sciences Centre, London, Ontario, Canada

🇨🇦

Toronto General Hospital, Toronto, Ontario, Canada

Efficacy and Safety of 90Y Microsphere Combined With FOLFIRI and Bevacizumab in Second-line Treatment of CRLM

Recruiting
Conditions
Colorectal Cancer Metastatic
Interventions
First Posted Date
2024-06-07
Last Posted Date
2024-06-07
Lead Sponsor
Zhongda Hospital
Target Recruit Count
30
Registration Number
NCT06447727
Locations
🇨🇳

Zhongda Hospital,Southeast University, Nanjing, Jiangsu, China

Preoperative Y-90 Radioembolization for Tumor Control and Future Liver Remnant Hypertrophy in Patients With Colorectal Liver Metastases

Phase 1
Recruiting
Conditions
Metastases
Interventions
First Posted Date
2022-01-19
Last Posted Date
2024-12-18
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
50
Registration Number
NCT05195710
Locations
🇺🇸

M D Anderson Cancer Center, Houston, Texas, United States

Combined Y-90 Selective Internal Radiation Therapy (Y-90 SIRT) and Stereotactic Body Radiation Therapy (SBRT) in Hepatic Malignancy.

Phase 1
Recruiting
Conditions
Liver Malignancy
Interventions
Device: Selective Internal Radiation Therapy
Radiation: Stereotactic Body Radiation Therapy
Diagnostic Test: PET/CT
Device: Therasphere
First Posted Date
2020-08-19
Last Posted Date
2024-11-06
Lead Sponsor
University of Michigan Rogel Cancer Center
Target Recruit Count
65
Registration Number
NCT04518748
Locations
🇺🇸

University of Michigan Rogel Cancer Center, Ann Arbor, Michigan, United States

Treatment for Bile Duct Cancer in the Liver

Phase 2
Completed
Conditions
Cholangio Carcinoma
Interventions
First Posted Date
2014-06-19
Last Posted Date
2023-04-21
Lead Sponsor
Chinese University of Hong Kong
Target Recruit Count
24
Registration Number
NCT02167711
Locations
🇭🇰

Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong, Hong Kong

Y-90 Alone or With Sorafenib for Pre-Transplant Hepatocellular Carcinoma

Phase 1
Completed
Conditions
Hepatocellular Carcinoma
Interventions
First Posted Date
2009-02-18
Last Posted Date
2016-09-15
Lead Sponsor
Northwestern University
Target Recruit Count
24
Registration Number
NCT00846131
Locations
🇺🇸

Northwestern Memorial Hospital, Chicago, Illinois, United States

Treatment of Patients With Advanced Renal Cancer With a Radiolabeled Antibody, Yttrium-90 Conjugated Chimeric G250

Phase 1
Completed
Conditions
Kidney Neoplasm
Renal Cancer
Renal Cell Carcinoma
Kidney Cancer
Interventions
First Posted Date
2005-09-20
Last Posted Date
2022-10-10
Lead Sponsor
Ludwig Institute for Cancer Research
Target Recruit Count
18
Registration Number
NCT00199875
Locations
🇺🇸

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Treatment of Tac-Expressing Cutaneous T-Cell Lymphoma (CTCL) and Adult T-Cell Leukemia (ATL) With Yttrium-90 Radiolabeled Anti-Tac

Phase 1
Completed
Conditions
Leukemia, T-Cell
Lymphoma, T-Cell, Cutaneous
First Posted Date
2002-12-10
Last Posted Date
2008-03-04
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
30
Registration Number
NCT00001249
Locations
🇺🇸

National Cancer Institute (NCI), Bethesda, Maryland, United States

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