Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor. It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. This drug is frequently known as Humira. It is produced by recombinant DNA technology using a mammalian cell expression system. This drug is available in a prefilled syringe form and convenient pen form for subcutaneous self-administered doses.
Several biosimilars to adalimumab. Adalimumab-atto was the first adalimumab biosimilar approved by the FDA in 2016. Adalimumab-adaz was approved by the FDA on October 31, 2018. Other biosimilars include adalimumab-fkjp, which was approved in July 2022, and adalimumab-bwwd, which was approved in August 2022. A biosimilar marketed as Hyrimoz, a high-concentration formulation of adalimumab, is also available.
Adalimumab is indicated for the following conditions:
Adalimumab has also been used off-label to treat Pyoderma gangrenosum.
IRIS Research and Development, Plantation, Florida, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Investigational Site Number 840403, Saint Petersburg, Florida, United States
Investigational Site Number 840229, Coral Gables, Florida, United States
Investigational Site Number 840140, Tampa, Florida, United States
University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States
Schneider Children's Hospital, Petach Tikva, Israel
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.