Vitamin B12

Generic Name: Vitamin B12

Brand Names: Infuvite Pediatric, Mvc-fluoride, Animi-3 With Vitamin D, Dodex, Fortaplex, Irospan 24/6 Kit, Cobex, Natafort, Infuvite, Vitafol-one, Nascobal, Mvi Pediatric, Hematogen, Folbic, Ferralet 90, Foltabs, Concept Ob, Pregvit, Tandem Plus, B-12

Drug Type: Small Molecule

Chemical Formula: C_₆₂H_₈₈CoN_₁₃O_₁₄P

CAS Number: 13408-78-1

Unique Ingredient Identifier: 8406EY2OQA

Background: Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria , and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-, methyl-, deoxyadenosyl- and hydroxy-cobala...

Indication: Nasal spray

The cyanocobalamin nasal spray is indicated for the maintenance of vitamin B12 concentrations after normalization with intramuscular vitamin B12 therapy in patients with deficiency of this vitamin who have no nervous system involvement .
...

Associated Conditions: Neuritis, Vitamin Deficiency, Vitamin B6 Deficiency, Diabetic Neuropathies, Vitamin B1 deficiency, Anemia, Pernicious, Vitamin B12 Deficiency, Convalescence, Iron Deficiency Anemia (IDA), Folate deficiency, Combined Vitamin B1 and B12 deficiency, Vitamin B12 concentration, Anemia

Associated Therapies: Vitamin supplementation, Nutritional supplementation

Clinical Trials

Vitamin B12 vs B3 for Nerve Regeneration and Functional Recovery After Pediatric Traumatic Brain Injury

Phase 3

Completed

Conditions: Traumatic Brain Injury

Interventions: Drug: Vitamin B3
Drug: Vitamin B12

First Posted Date: 2023-07-24

Last Posted Date: 2023-07-24

Lead Sponsor: KRL Hospital, Islamabad

Target Recruit Count: 300

Registration Number: NCT05958277

Locations: 🇵🇰
KRL Hospital, Islamabad, Pakistan

Intrathecal Pemetrexed for Leptomeningeal Metastasis

Phase 1

Completed

Conditions: Leptomeningeal Metastases

Interventions: Drug: Pemetrexed (1)
Drug: Pemetrexed (2)
Drug: Folic Acid
Drug: Vitamin B12
Drug: Dexamethasone

First Posted Date: 2022-03-22

Last Posted Date: 2024-11-11

Lead Sponsor: The First Hospital of Jilin University

Target Recruit Count: 34

Registration Number: NCT05289908

Locations: 🇨🇳
The First Hospital of Jilin University, Changchun, Jilin, China

GLP-1 Therapy: The Role of IL-6 Signaling and Adipose Tissue Remodeling in Metabolic Response

Phase 4

Completed

Conditions: Glucose Intolerance
Overweight and Obesity
Drug Effect
Adiposity

Interventions: Drug: Cyanocobalamin
Drug: Dulaglutide

First Posted Date: 2020-05-13

Last Posted Date: 2024-12-05

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 23

Registration Number: NCT04387201

Locations: 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States

Vitamin B12 for Carpal Tunnel Syndrome

Not Applicable

Withdrawn

Conditions: Carpal Tunnel Syndrome

Interventions: Drug: Normal saline
Drug: Vitamin B12

First Posted Date: 2019-01-14

Last Posted Date: 2020-10-08

Lead Sponsor: Tri-Service General Hospital

Registration Number: NCT03802422

Locations: 🇨🇳
Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, Taipei, Neihu District, Taiwan

Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics

Phase 2

Conditions: Schizophrenia
Oxidative Stress
Drug Induced Movement Disorder, Unspecified

Interventions: Drug: Placebo Oral Tablet
Drug: Cobalamin
Drug: Pyridoxine

First Posted Date: 2018-12-31

Last Posted Date: 2019-12-18

Lead Sponsor: Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara

Target Recruit Count: 45

Registration Number: NCT03790345

Locations: 🇧🇷
Núcleo de Pesquisa e Desenvolvimento de Medicamentos - UFC, Fortaleza, CE, Brazil

Effects of Vitamin B12 Treatment in Singers

Early Phase 1

Completed

Conditions: Vitamin B 12 Deficiency

Interventions: Drug: Placebo
Drug: Cyanocobalamin

First Posted Date: 2018-02-19

Last Posted Date: 2019-04-09

Lead Sponsor: University of Southern California

Target Recruit Count: 20

Registration Number: NCT03437824

Locations: 🇺🇸
Keck Medicine of USC - Downtown Los Angeles, Los Angeles, California, United States

Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer

Phase 1

Completed

Conditions: Leptomeningeal Metastases

Interventions: Drug: Pemetrexed
Drug: Dexamethasone
Drug: Folic Acid
Drug: Vitamin B12

First Posted Date: 2017-04-05

Last Posted Date: 2019-03-19

Lead Sponsor: The First Hospital of Jilin University

Target Recruit Count: 13

Registration Number: NCT03101579

Locations: 🇨🇳
The First Hospital of Jilin University, Changchun, Jilin, China

Effect of Vitamin B on Plasma Neurofilament Light Protein (NFL) in HIV-infected Individuals With Increased Plasma Homocysteine

Phase 2

Conditions: HIV

Interventions: Drug: Cyanocobalamin
Drug: Folate
Drug: Pyridoxine

First Posted Date: 2016-05-16

Last Posted Date: 2018-01-02

Lead Sponsor: Göteborg University

Target Recruit Count: 60

Registration Number: NCT02773147

Locations: 🇸🇪
Department of Infectious Diseases, Sahlgrenska university hospital, Gothenburg, Sweden

Vitamin D and Vitamin B12 Supplementation With Pegylated Interferon-Alfa Plus Ribavirin for Treating Chronic Hepatitis C

Phase 4

Terminated

Conditions: RNA Virus Infections
Flaviviridae Infections
Hepatitis C
Hepatitis C, Chronic

Interventions: Drug: Vitamin D
Drug: Vitamin B 12

First Posted Date: 2014-04-22

Last Posted Date: 2016-08-24

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 85

Registration Number: NCT02120274

Locations: 🇧🇷
Outpatient Clinic of Viral Hepatitis (NUPAIG), São Paulo, Brazil

Phase II Study of Folotyn With Leucovorin to Prevent/Reduce Mucositis in Patients With Hematological Malignancies

Phase 2

Completed

Conditions: Relapsed Peripheral T-Cell Lymphoma
Refractory Peripheral T-Cell Lymphoma

Interventions: Drug: Folotyn and Leucovorin
Drug: Folic Acid
Drug: Vitamin B12

First Posted Date: 2014-04-08

Last Posted Date: 2019-11-20

Lead Sponsor: Acrotech Biopharma Inc.

Target Recruit Count: 36

Registration Number: NCT02106650

Locations: 🇺🇸
City of Hope, Duarte, California, United States
🇺🇸
Cancer Center of Kansas, Wichita, Kansas, United States
🇺🇸
Seattle Cancer Care Alliance, Seattle, Washington, United States

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