Diazoxide
- Generic Name
- Diazoxide
- Brand Names
- Proglycem
- Drug Type
- Small Molecule
- Chemical Formula
- C8H7ClN2O2S
- CAS Number
- 364-98-7
- Unique Ingredient Identifier
- O5CB12L4FN
- Background
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels. It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insu...
- Indication
Oral diazoxide is indicated to manage hypoglycemia due to hyperinsulinism associated with conditions such as inoperable islet cell adenoma or carcinoma, and extrapancreatic malignancy in adults, or leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, and adenomatosis in infants and children. In infant...
- Associated Conditions
- Hyperinsulinemic Hypoglycemia
- Associated Therapies
- -
The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients
- Conditions
- Interventions
- First Posted Date
- 2018-09-26
- Last Posted Date
- 2023-06-05
- Lead Sponsor
- Albert Einstein College of Medicine
- Registration Number
- NCT03685773
- Locations
- 🇺🇸
Albert Einstein College of Medicine, Bronx, New York, United States
Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)
- Conditions
- Interventions
- First Posted Date
- 2018-07-31
- Last Posted Date
- 2023-03-17
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 17
- Registration Number
- NCT03608163
- Locations
- 🇺🇸
Albert Einstein College of Medicine, Bronx, New York, United States
Use of Functional MRI to Assess Functional Hypothalamic Activation in Response to Diazoxide
- Conditions
- Interventions
- First Posted Date
- 2018-06-25
- Last Posted Date
- 2023-06-05
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 24
- Registration Number
- NCT03566511
- Locations
- 🇺🇸
Albert Einstein College of Medicine, Bronx, New York, United States
Regulation of Endogenous Glucose Production by Central KATP Channels
- Conditions
- Interventions
- First Posted Date
- 2018-05-30
- Last Posted Date
- 2024-12-11
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 100
- Registration Number
- NCT03540758
- Locations
- 🇺🇸
Albert Einstein College of Medicine, Bronx, New York, United States
Pasireotide Treatment for Neuroendocrine Tumor
- Conditions
- Interventions
- First Posted Date
- 2016-05-20
- Last Posted Date
- 2022-03-04
- Lead Sponsor
- University of Maryland, Baltimore
- Registration Number
- NCT02779257
Does Enhanced Glutamate Transporter Function Produce Antidepressant Effects in People With Major Depression?
- First Posted Date
- 2014-01-30
- Last Posted Date
- 2017-10-13
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 10
- Registration Number
- NCT02049385
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Use of Diazoxide in Acute Hypoglycaemia
- First Posted Date
- 2011-12-08
- Last Posted Date
- 2019-10-14
- Lead Sponsor
- University of Dundee
- Target Recruit Count
- 12
- Registration Number
- NCT01488136
- Locations
- 🇬🇧
NHS Tayside, Dundee, United Kingdom
Central Mechanisms That Regulate Glucose Metabolism in Humans
- Conditions
- Interventions
- First Posted Date
- 2009-12-09
- Last Posted Date
- 2022-11-16
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 10
- Registration Number
- NCT01028846
- Locations
- 🇺🇸
Albert Einstein College of Medicine, Bronx, New York, United States
Diazoxide In the Management Of Hypoglycemic Neonates
- First Posted Date
- 2009-10-14
- Last Posted Date
- 2009-10-14
- Lead Sponsor
- University of Saskatchewan
- Target Recruit Count
- 100
- Registration Number
- NCT00994149
- Locations
- 🇨🇦
Royal University Hospital, Saskatoon, Saskatchewan, Canada
Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy
- First Posted Date
- 2009-05-04
- Last Posted Date
- 2017-11-17
- Lead Sponsor
- The Hospital for Sick Children
- Target Recruit Count
- 9
- Registration Number
- NCT00892073
- Locations
- 🇨🇦
The Hospital for Sick Children, Toronto, Ontario, Canada
Drug Development Updates
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