Naloxone
- Generic Name
- Naloxone
- Brand Names
- Kloxxado, Narcan, Suboxone, Targin, Targiniq, Zimhi, Zubsolv, Nyxoid
- Drug Type
- Small Molecule
- Chemical Formula
- C19H21NO4
- CAS Number
- 465-65-6
- Unique Ingredient Identifier
- 36B82AMQ7N
- Background
Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other d...
- Indication
Naloxone nasal sprays are indicated for the reversal of an opioid overdose or suspected opioid overdose: it is intended for immediate administration as emergency therapy in settings where opioids may be present. Intramuscular, intravenous, and subcutaneous injections are indicated for complete or partial reversal of opioid depression, diagnosis of known or s...
- Associated Conditions
- Opioid Dependence, Opioid Overdose, Pruritus, Respiratory Depression, Septic Shock, Severe Pain, Moderate Pain, Suspected Opioid Overdose
- Associated Therapies
- Emergency Care
Pain Relief After Corneal Collagen Cross-Linking
- Conditions
- Interventions
- First Posted Date
- 2024-01-19
- Last Posted Date
- 2024-01-19
- Lead Sponsor
- Assaf-Harofeh Medical Center
- Target Recruit Count
- 51
- Registration Number
- NCT06212830
- Locations
- 🇮🇱
Shamir Medical Center (Assaf Harofeh), Be'er Ya'aqov, Israel
Multi-System Analysis of Opioid Receptor Binding
- Conditions
- Interventions
- First Posted Date
- 2022-09-06
- Last Posted Date
- 2024-07-24
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 60
- Registration Number
- NCT05528848
- Locations
- 🇺🇸
University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, United States
RM1 Project 1 - tAN Naloxone
- First Posted Date
- 2022-08-05
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 136
- Registration Number
- NCT05490134
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation
- Conditions
- Interventions
- First Posted Date
- 2022-05-04
- Last Posted Date
- 2023-02-16
- Target Recruit Count
- 45
- Registration Number
- NCT05360030
- Locations
- 🇨🇳
The second affiliated hospital of Zhejiang University hangzhou, Hangzhou, Zhejiang, China
Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms
- Conditions
- Interventions
- First Posted Date
- 2021-12-02
- Last Posted Date
- 2024-10-10
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 120
- Registration Number
- NCT05142267
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Vaped Marijuana to Attenuate Naloxone-Precipitated Withdrawal
- First Posted Date
- 2021-11-10
- Last Posted Date
- 2024-12-19
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 2
- Registration Number
- NCT05114460
- Locations
- 🇺🇸
New York State Psychiatric Institute, New York, New York, United States
European Cohort Study of the Effectiveness of Take Home Naloxone
- First Posted Date
- 2021-10-08
- Last Posted Date
- 2023-03-29
- Lead Sponsor
- King's College London
- Target Recruit Count
- 6000
- Registration Number
- NCT05072249
- Locations
- 🇬🇧
Public Health Wales, Cardiff, United Kingdom
🇸🇪Stockholm Centre for Dependency Disorders, Stockholm, Sweden
🇬🇧South London and the Maudsley, London, United Kingdom
Opioid Antagonism in Hypogonadotropic Hypogonadism
- First Posted Date
- 2021-07-23
- Last Posted Date
- 2024-07-16
- Lead Sponsor
- Stephanie B. Seminara, MD
- Target Recruit Count
- 23
- Registration Number
- NCT04975334
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Opioid Antagonism in Individuals Ascertained Through the Partners HealthCare Biobank
- First Posted Date
- 2021-07-23
- Last Posted Date
- 2024-07-16
- Lead Sponsor
- Stephanie B. Seminara, MD
- Target Recruit Count
- 49
- Registration Number
- NCT04975347
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain
- First Posted Date
- 2021-04-20
- Last Posted Date
- 2024-05-23
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 259
- Registration Number
- NCT04851301
- Locations
- 🇺🇸
Luana Colloca, Baltimore, Maryland, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.