Naloxone
- Generic Name
- Naloxone
- Brand Names
- Kloxxado, Narcan, Suboxone, Targin, Targiniq, Zimhi, Zubsolv, Nyxoid
- Drug Type
- Small Molecule
- Chemical Formula
- C19H21NO4
- CAS Number
- 465-65-6
- Unique Ingredient Identifier
- 36B82AMQ7N
- Background
Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other d...
- Indication
Naloxone nasal sprays are indicated for the reversal of an opioid overdose or suspected opioid overdose: it is intended for immediate administration as emergency therapy in settings where opioids may be present. Intramuscular, intravenous, and subcutaneous injections are indicated for complete or partial reversal of opioid depression, diagnosis of known or s...
- Associated Conditions
- Opioid Dependence, Opioid Overdose, Pruritus, Respiratory Depression, Septic Shock, Severe Pain, Moderate Pain, Suspected Opioid Overdose
- Associated Therapies
- Emergency Care
A Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN)
- First Posted Date
- 2012-08-30
- Last Posted Date
- 2016-12-16
- Lead Sponsor
- Mundipharma Korea Ltd
- Target Recruit Count
- 73
- Registration Number
- NCT01675531
- Locations
- 🇰🇷
Seoul ST.Mary Hospital, Seoul, Banpogu, Korea, Republic of
Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time.
- First Posted Date
- 2012-05-11
- Last Posted Date
- 2012-05-11
- Lead Sponsor
- University Medicine Greifswald
- Target Recruit Count
- 16
- Registration Number
- NCT01596764
- Locations
- 🇩🇪
Department of Clinical Pharmacology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany
The Effects of ∆-9-THC and Naloxone in Humans
- First Posted Date
- 2012-05-04
- Last Posted Date
- 2022-03-09
- Lead Sponsor
- Yale University
- Target Recruit Count
- 6
- Registration Number
- NCT01591629
- Locations
- 🇺🇸
VA Connecticut Healthcare System, West Haven, Connecticut, United States
Clinical Trial on Binge Eating Disorder, Treatment With Naloxone Spray
- First Posted Date
- 2012-03-30
- Last Posted Date
- 2012-03-30
- Lead Sponsor
- Lightlake Sinclair Ltd.
- Target Recruit Count
- 138
- Registration Number
- NCT01567670
Comparison of Two Naloxone Infusion Rates on the Postoperative Recovery of Patients Undergoing Spine Fusion Surgery
- Conditions
- Interventions
- First Posted Date
- 2012-02-13
- Last Posted Date
- 2020-09-10
- Lead Sponsor
- Children's Mercy Hospital Kansas City
- Target Recruit Count
- 84
- Registration Number
- NCT01531439
- Locations
- 🇺🇸
Children's Mercy Hospital, Kansas City, Missouri, United States
Naloxone and Intravenous Methylnaltrexone Effects on Bladder Function
- Conditions
- Interventions
- First Posted Date
- 2011-06-07
- Last Posted Date
- 2023-04-12
- Lead Sponsor
- Bausch Health Americas, Inc.
- Target Recruit Count
- 15
- Registration Number
- NCT01367561
- Locations
- 🇺🇸
Progenics Pharmaceuticals, Inc., Tarrytown, New York, United States
Opioid Effects on Swallowing and Esophageal Sphincter Pressure
- Conditions
- Interventions
- First Posted Date
- 2010-08-31
- Last Posted Date
- 2012-02-02
- Lead Sponsor
- Region Örebro County
- Target Recruit Count
- 14
- Registration Number
- NCT01191645
- Locations
- 🇸🇪
Örebro University Hospital, Örebro, Sweden
A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2010-04-23
- Last Posted Date
- 2018-11-05
- Lead Sponsor
- Ullevaal University Hospital
- Target Recruit Count
- 85
- Registration Number
- NCT01109511
- Locations
- 🇳🇴
Dept of Anesthesiology, Oslo University Hospital, Ullevaal, Oslo, Norway
Subjective Analgesic Effects of Naloxone and Virtual Reality
- First Posted Date
- 2010-04-19
- Last Posted Date
- 2012-08-21
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 50
- Registration Number
- NCT01105871
- Locations
- 🇺🇸
University of Washington Medical Center, Seattle, Washington, United States
Naloxone for the Treatment of Opioid-Induced Pruritus
- First Posted Date
- 2010-02-18
- Last Posted Date
- 2017-10-26
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 92
- Registration Number
- NCT01071057
- Locations
- 🇨🇦
British Columbia Children's Hospital Department of Anesthesia, Vancouver, British Columbia, Canada
Drug Development Updates
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