Diazoxide
- Generic Name
- Diazoxide
- Brand Names
- Proglycem
- Drug Type
- Small Molecule
- Chemical Formula
- C8H7ClN2O2S
- CAS Number
- 364-98-7
- Unique Ingredient Identifier
- O5CB12L4FN
- Background
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels. It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insu...
- Indication
Oral diazoxide is indicated to manage hypoglycemia due to hyperinsulinism associated with conditions such as inoperable islet cell adenoma or carcinoma, and extrapancreatic malignancy in adults, or leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, and adenomatosis in infants and children. In infant...
- Associated Conditions
- Hyperinsulinemic Hypoglycemia
- Associated Therapies
- -
Insulin and Polycystic Ovary Syndrome
- First Posted Date
- 2008-05-23
- Last Posted Date
- 2017-06-14
- Lead Sponsor
- Virginia Commonwealth University
- Target Recruit Count
- 21
- Registration Number
- NCT00683774
- Locations
- 🇺🇸
General Clinical Research Center, Richmond, Virginia, United States
DZX Mediated Insulin Suppression in Obese Men
- Conditions
- Interventions
- First Posted Date
- 2008-03-07
- Last Posted Date
- 2014-11-06
- Lead Sponsor
- Rijnstate Hospital
- Target Recruit Count
- 51
- Registration Number
- NCT00631033
- Locations
- 🇳🇱
Rijnstate Hospital, Arnhem, Netherlands
Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions
- Conditions
- First Posted Date
- 2006-03-24
- Last Posted Date
- 2011-02-18
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 40
- Registration Number
- NCT00306683
- Locations
- 🇫🇷
Hopital Kremlin-Bicetre, Paris, France
Ischemic Injury and Ischemic Preconditioning in Diabetes
- Conditions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2007-04-05
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT00184821
- Locations
- 🇳🇱
Clinical Research Centre Nijmegen; Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands
Diazoxide-Mediated Insulin Suppression in Hyperinsulinemic Obese Men
- Conditions
- First Posted Date
- 2005-09-09
- Last Posted Date
- 2008-02-29
- Lead Sponsor
- Rijnstate Hospital
- Target Recruit Count
- 25
- Registration Number
- NCT00151684
- Locations
- 🇳🇱
Rijnstate Hospital, Arnhem, Netherlands
Efficacy of Diazoxide in Type 1 Diabetes
- Conditions
- First Posted Date
- 2005-08-19
- Last Posted Date
- 2011-07-18
- Lead Sponsor
- Grill, Valdemar, M.D.
- Target Recruit Count
- 40
- Registration Number
- NCT00131755
- Locations
- 🇳🇴
University Hospital of Trondheim, Trondheim, Norway
Drug Development Updates
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