Imatinib

Generic Name: Imatinib

Brand Names: Gleevec, Glivec, Imatinib Teva, Imatinib Accord

Drug Type: Small Molecule

Chemical Formula: C_₂₉H_₃₁N_₇O

CAS Number: 152459-95-5

Unique Ingredient Identifier: BKJ8M8G5HI

Background: Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with a daily dosage of 300 mg or more and ...

Indication: Imatinib is indicated for the treatment of adult and pediatric chronic myeloid leukemia with Philadelphia chromosome mutation (Ph+) in blast crisis, accelerated phase, or chronic phase after IFN-alpha therapy failure.Additionally, imatinib is also indicated to treat adult and pediatric Ph+ acute lymphoblastic leukemia, adult myelodysplastic/myeloproliferativ...

Associated Conditions: Accelerated Phase Chronic Myelogenous Leukemia (CML), Aggressive Systemic Mastocytosis, Chordomas, Chronic Eosinophilic Leukemia, FIP1L1-PDGFRα fusion kinase status unknown Chronic eosinophilic leukemia, FIP1L1-PDGFRα fusion kinase status unknown Hypereosinophilic syndrome, Gastrointestinal Stromal Tumor (GIST), Hypereosinophilic Syndrome (HES), Metastatic Gastrointestinal Stromal Tumor (GIST), Metastatic Melanoma, Myelodysplastic Syndrome, Myeloproliferative Disorders (MPD), Refractory Acute Lymphoblastic Leukemia (ALL), Blast phase Chronic myeloid leukemia, CKit mutational status unknown Aggressive systemic mastocytosis, Metastatic Dermatofibrosarcoma protuberans, Newly diagnosed Acute Lymphoblastic Leukaemia, Newly diagnosed, chronic phase Chronic myeloid leukemia, Recurrent Dermatofibrosarcoma protuberans, Refractory, chronic phase Chronic myeloid leukemia, Unresectable Gastrointestinal stromal tumor

Associated Therapies: -

Clinical Trials

Study Comparing Imatinib With Chemotherapy as Induction in Elderly Patients With Philadelphia Positive Acute Lymphoblastic Leukemia (ALL)

Phase 2

Conditions: Philadelphia Positive Acute Lymphoblastic Leukemia
Lymphoid Blastic Phase of Chronic Myeloid Leukemia

First Posted Date: 2005-09-20

Last Posted Date: 2007-10-19

Lead Sponsor: Johann Wolfgang Goethe University Hospital

Registration Number: NCT00199186

Locations: 🇩🇪
Medizinische Klinik II, Johann Wolfgang Goethe Universität, Frankfurt/Main, Germany

Bevacizumab, Erlotinib, and Imatinib in the Treatment of Advanced Renal Cell Carcinoma

Phase 1

Completed

Conditions: Clear Cell Renal Cell Carcinoma

Interventions: Drug: Bevacizumab
Drug: Erlotinib
Drug: Imatinib

First Posted Date: 2005-09-19

Last Posted Date: 2013-01-31

Lead Sponsor: SCRI Development Innovations, LLC

Target Recruit Count: 94

Registration Number: NCT00193258

Gleevec Combined With Camptosar Plus Paraplatin in Previously Untreated Extensive Stage Small Cell Lung Cancer

Phase 2

Completed

Conditions: Lung Cancer

First Posted Date: 2005-09-19

Last Posted Date: 2010-06-28

Lead Sponsor: SCRI Development Innovations, LLC

Target Recruit Count: 60

Registration Number: NCT00193349

Docetaxel Plus Imatinib Mesylate in Metastatic Breast Cancer

Phase 2

Completed

Conditions: Breast Cancer

Interventions: Drug: Imatinib
Drug: Docetaxel

First Posted Date: 2005-09-19

Last Posted Date: 2016-05-27

Lead Sponsor: SCRI Development Innovations, LLC

Target Recruit Count: 37

Registration Number: NCT00193180

Locations: 🇺🇸
Baton Rouge General Medical Center, Baton Rouge, Louisiana, United States
🇺🇸
Methodist Cancer Center, Omaha, Nebraska, United States
🇺🇸
Tennessee Oncology, Nashville, Tennessee, United States

and more 3 locations

Glivec Phase II Pediatric Study

Phase 2

Terminated

Conditions: Cancer

First Posted Date: 2005-09-16

Last Posted Date: 2006-09-11

Lead Sponsor: Gustave Roussy, Cancer Campus, Grand Paris

Target Recruit Count: 36

Registration Number: NCT00180830

Locations: 🇫🇷
Institut Gustave-Roussy, Villejuif, France
🇳🇱
Emma Kinderziekenhuis AMC, Amsterdam, Netherlands
🇬🇧
Birmingham Children's Hospital, Birmingham, United Kingdom