Plasmin

Generic Name
Plasmin
Brand Names
Ryplazim
Drug Type
Biotech
Chemical Formula
-
CAS Number
9001-91-6
Unique Ingredient Identifier
1EF190B6M7
Background

Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as fibrinolysin - as part of the fibrinolytic pathway that breaks down fibrin blood clots. This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond the site of injury.

In June 2021, the FDA approved a plasma-derived plasminogen (Ryplazim, human plasminogen-tvmh) for the treatment of type 1 plasminogen deficiency (hypoplasminogenemia). It is the first and only FDA-approved treatment for this condition, which causes wood-like lesions to form on the mucous membranes of patients, providing an unmet medical need for patients with this rare congenital disease.

Indication

Plasma-derived human plasminogen, marketed under the brand name Ryplazim, is indicated for the treatment of patients with plasminogen deficiency type 1 (hypoplasminogenemia).

Associated Conditions
Type I Plasminogen Deficiency
Associated Therapies
-

Sponsor Initiated Expanded Access Protocol, Intermediate-Size Patient Population

First Posted Date
2020-10-14
Last Posted Date
2023-10-05
Lead Sponsor
Kedrion S.p.A.
Registration Number
NCT04586062

A Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment (PVD)

Phase 1
Terminated
Conditions
Interventions
First Posted Date
2006-07-04
Last Posted Date
2019-06-21
Lead Sponsor
Bausch & Lomb Incorporated
Target Recruit Count
4
Registration Number
NCT00347646
Locations
🇺🇸

University Hospitals of Cleveland, Cleveland, Ohio, United States

Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2006-07-04
Last Posted Date
2019-06-21
Lead Sponsor
Bausch & Lomb Incorporated
Target Recruit Count
29
Registration Number
NCT00348439
Locations
🇺🇸

Emory University, Atlanta, Georgia, United States

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