Calcium carbonate

Overview

Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.

Indication

For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.

Associated Conditions

Bloating
Calcium Deficiency
Calcium Metabolism Disorders
Calcium and Vitamin D Deficiencies
Colic
Dyspepsia
Gastric Ulcer
Gastroesophageal Reflux
Haemorrhoids
Heartburn
Hot Flashes
Hyperacidity
Hyperphosphataemia
Low Bone Density
Osteodystrophy
Osteomalacia
Osteoporosis
Post Operative Gas
Postmenopausal Osteoporosis
Proctitis
Reflux Acid
Rickets
Vertebral Fractures
Calcium loss
Gastrointestinal ulceration

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Oral Calcium Supplementation in Labor	2025/07/09	NCT07056062	Not Applicable	Completed	Arrowhead Regional Medical Center
Calcium-Phosphorus Regulation Therapy on Heart Valve Disease	2024/10/28	NCT06660524	Phase 4	Recruiting	China National Center for Cardiovascular Diseases
Effect of Laser Acupuncture on Forearm Bone Mineral Density and Wrist Pain in Osteoporotic Postmenopausal Women	2022/09/29	NCT05559619	Not Applicable	Completed	Cairo University
The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With TDF	2022/04/06	NCT05313477	Phase 4	Completed	Mahidol University
A Study of the Drug Interactions Between Danicopan and Cyclosporine, Tacrolimus, Antacids, and Omeprazole in Healthy Adults	2021/11/05	NCT05109390	Phase 1	Completed	Alexion Pharmaceuticals, Inc.
A Study to Evaluate the One-way Interaction of Calcium Carbonate, Omeprazole, or Rifampin on ACP-196	2021/06/07	NCT04914936	Phase 1	Completed	Acerta Pharma BV
Investigation of the Efficacy of Acamprosate and Calcium in Comparison to Placebo as Validation of a Behavioural Test for Alcohol Dependence	2018/08/17	NCT03634917	Phase 3	Completed	Technische Universität Dresden
A Dose Finding Study of CycloSam® Combined With External Beam Radiotherapy	2018/08/02	NCT03612466	Phase 1	Withdrawn	Albert Einstein College of Medicine
The Effectiveness and Safety of Calcium Carbonate in Chronic Kidney Disease With Normophosphatemia	2018/06/08	NCT03550534	Not Applicable	Completed	Indonesia University
Efficacy of Calcium Citrate Versus Calcium Carbonate for the Management of Chronic Hypoparathyroidism	2018/02/08	NCT03425747	Phase 4	Completed	Campus Bio-Medico University

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
PRENATAL PLUS	AvPAK	50268-677	ORAL	200 mg in 1 1	4/12/2022
KOSHER MEDS antacid	Mollec Inc	82179-005	ORAL	500 mg in 1 1	6/23/2025
Vitramyn	PureTek Corporation	59088-193	ORAL	200 mg in 1 1	1/11/2023
TUMS ULTRA	Haleon US Holdings LLC	0135-0181	ORAL	1000 mg in 1 1	5/22/2025
TUMS ULTRA	Haleon US Holdings LLC	0135-0180	ORAL	1000 mg in 1 1	5/22/2025
PRENATAL PLUS	Carilion Materials Management	68151-2640	ORAL	200 mg in 1 1	4/1/2013
Calcium Carbonate Antacid Assorted Berries	FSA STORE INC.	81522-361	ORAL	750 mg in 1 1	4/18/2025
Tumeez Organic Apple	BFY LLC	72427-2000	ORAL	200 mg in 7 g	5/7/2025
MagneBind 400 Rx	Carilion Materials Management	68151-4243	oral	80 mg in 1 1	4/9/2014
Keylosa	Novian Pharmaceuticals	83146-003	ORAL	200 mg in 1 1	10/6/2023

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
GAVISCON LIQUID	RECKITT BENCKISER HEALTHCARE (UK) LTD	SIN09494P	SUSPENSION	160 mg/10 ml	9/13/1997
GAVISCON DOUBLE ACTION TABLETS	RECKITT BENCKISER HEALTHCARE (UK) LIMITED	SIN14194P	TABLET, CHEWABLE	187.5MG	7/17/2012
RENNIE TABLET	Delpharm Gaillard	SIN08733P	TABLET	680 mg	5/27/1996
GAVISCON LIQUID SACHETS	RECKITT BENCKISER HEALTHCARE (UK) LIMITED	SIN13738P	SUSPENSION	160MG/10ML	11/23/2009
GAVISCON PEPPERMINT TABLETS	RECKITT BENCKISER HEALTHCARE (UK) LIMITED	SIN13947P	TABLET, CHEWABLE	80MG	4/14/2011
GASCOVID LIQUID	Hovid Berhad	SIN16041P	SUSPENSION	160 mg/10ml	11/17/2020
GAVISCON DOUBLE ACTION LIQUID, SUSPENSION	RECKITT BENCKISER HEALTHCARE (UK) LIMITED	SIN14016P	SUSPENSION	325MG/10ML	9/19/2011
OHTA'S ISAN ANTACID POWDER	OHTA'S ISAN CO LTD	SIN05820P	POWDER	497 mg/1.3 g	5/3/1991

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
OHTA'S ISAN POWDER	N/A	Man Hing Medicine Traders	N/A	N/A	4/13/1987
STROCAIN TAB	N/A	EISAI (HONG KONG) COMPANY LIMITED	N/A	N/A	9/6/1988
SPAGASTROL TAB	N/A	WILCOME PHARMACEUTICAL COMPANY LIMITED	N/A	N/A	3/5/1987

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
Kids Calcium + D3 Corbiere (export)	286468	Sanofi-Aventis Healthcare Pty Ltd T/A Sanofi Consumer Healthcare	Medicine	A	3/7/2017
Energy Multi	453128	Australian Pharmaceutical Industries Pty Ltd	Medicine	A	6/21/2024
Flechos+	285828	Valentior	Medicine	A	2/17/2017
GAVISCON DUAL ACTION mixed berry flavour oral liquid bottle	328032	Reckitt Benckiser Pty Ltd	Medicine	A	12/23/2019
Berocca Performance Original effervescent tablets	193893	Bayer Australia Ltd	Medicine	A	1/17/2012
GAVISCON EXTRA STRENGTH peppermint flavour chewable tablet blister pack	156040	Reckitt Benckiser Pty Ltd	Medicine	A	10/21/2008
Calcium + D3 Corbiere	291608	Sanofi-Aventis Healthcare Pty Ltd T/A Sanofi Consumer Healthcare	Medicine	A	7/17/2017
HKSG Swisse Kids Bone Health	321126	Swisse Wellness Pty Ltd	Medicine	A	7/31/2019
Liquid Calcium	310127	RBK Nutraceuticals Pty Ltd	Medicine	A	10/4/2018
Wealthy Health Bio-Calcium Liquid soft capsules	302490	Universal Pharmaceuticals Pty Ltd	Medicine	A	5/1/2018

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
R90 ANTI-ACIDE TAB	dr reckeweg canada	02001004	Tablet - Oral	300 MG / TAB	12/31/1993
R35 CHADONTIN LIQ	dr reckeweg and co	00864609	Drops - Oral	30 D / D	12/31/1989
ASPIRIN PLUS STOMACH GUARD TAB	sterling winthrop inc.	02078449	Tablet - Oral	160 MG / TAB	12/31/1994
R-57 DPS	dr reckeweg canada	02090384	Drops - Oral	30 D / 10 ML	12/31/1994
CALCIUM TAB 600MG	PHARMAVITE LLC	00722332	Tablet - Oral	1.5 G	12/31/1987
GRAPHITES HOMACCORD (GRAPHITE:10D,30D,200D/100ML)(CALCIUM CARBONATE:10D,30D,200D/100ML)	Biologische Heilmittel Heel Gmbh	01988468	Liquid - Oral	10 D / 100 ML	12/31/1992
GRAMCAL EVT 1000MG	Sandoz Canada Inc	00259497	Tablet (Effervescent) - Oral	1.75 G / EVT	12/31/1972
CALMICID	melaleuca of canada inc.	02242772	Tablet - Oral	420 MG	1/8/2001
PEPCID COMPLETE	mcneil consumer healthcare division of johnson & johnson inc	02243053	Tablet (Chewable) - Oral	800 MG	5/14/2001
TUMS ASSORTED MINT TAB	smithkline beecham consumer healthcare, division of smithkline beecham inc.	02016613	Tablet - Oral	500 MG / TAB	12/31/1993

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
IDEOS UNIDIA 1000 mg/880 UI GRANULADO EFERVESCENTE	Theramex Ireland Limited	68006	GRANULADO EFERVESCENTE	Medicamento Sujeto A Prescripción Médica	Commercialized
IDEOS 500 MG/400 UI COMPRIMIDOS MASTICABLES	Theramex Ireland Limited	61159	COMPRIMIDO MASTICABLE	Medicamento Sujeto A Prescripción Médica	Commercialized
RENNIE 680 MG/80 MG COMPRIMIDOS MASTICABLES CON SACAROSA	Bayer Hispania S.L.	52873	COMPRIMIDO MASTICABLE	Sin Receta	Commercialized
GAVISCON FORTE SUSPENSION ORAL EN SOBRES	Reckitt Benckiser Healthcare S.A.	79018	SUSPENSIÓN ORAL	Sin Receta	Commercialized
MASTICAL D SABOR LIMON 500 mg/400 UI COMPRIMIDOS MASTICABLES	Cheplapharm Arzneimittel Gmbh	67800	COMPRIMIDO MASTICABLE	Medicamento Sujeto A Prescripción Médica	Commercialized
CALCIO/VITAMINA D3 SANDOZ 1000 MG/ 880 UI COMPRIMIDOS MASTICABLES	Sandoz Farmaceutica S.A.	76617	COMPRIMIDO MASTICABLE	Medicamento Sujeto A Prescripción Médica	Commercialized
CALCIO/VITAMINA D3 ROVI 1000 MG/880 UI COMPRIMIDOS MASTICABLES	Laboratorios Farmaceuticos Rovi S.A.	81988	COMPRIMIDO MASTICABLE	Medicamento Sujeto A Prescripción Médica	Commercialized
CALODIS 1000 mg/880 UI COMPRIMIDOS EFERVESCENTES	Esteve Pharmaceuticals S.A.	68295	COMPRIMIDO EFERVESCENTE	Medicamento Sujeto A Prescripción Médica	Commercialized
ADIAVAL 1.000 MG/880 UI COMPRIMIDOS MASTICABLES EFG	Lacer S.A.	81862	COMPRIMIDO MASTICABLE	Medicamento Sujeto A Prescripción Médica	Commercialized
TRIDEPOS 70 MG + 500 MG/800 UI COMPRIMIDOS	Meda Pharma S.L.	81769	COMPRIMIDO	Medicamento Sujeto A Prescripción Médica	Not Commercialized

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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