Prasugrel
- Generic Name
- Prasugrel
- Brand Names
- Effient, Efient, Prasugrel Viatris (previously Prasugrel Mylan)
- Drug Type
- Small Molecule
- Chemical Formula
- C20H20FNO3S
- CAS Number
- 150322-43-3
- Unique Ingredient Identifier
- 34K66TBT99
- Background
Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversibly binds to P2Y12 type ADP receptors on ...
- Indication
用于心力衰竭、卒中、不稳定心绞痛等心脑血管疾病以及有急性冠状动脉综合征需要进行经皮冠脉介入术的患者。
- Associated Conditions
- Cardiovascular Events
- Associated Therapies
- -
Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting
- First Posted Date
- 2015-07-01
- Last Posted Date
- 2019-04-25
- Lead Sponsor
- Korea University Anam Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT02487732
- Locations
- 🇰🇷
Korea University Anam Hospital, Seoul, Korea, Republic of
Reducing Micro Vascular Dysfunction in Acute Myocardial Infarction by Ticagrelor
- First Posted Date
- 2015-04-21
- Last Posted Date
- 2018-05-03
- Lead Sponsor
- Amsterdam UMC, location VUmc
- Target Recruit Count
- 110
- Registration Number
- NCT02422888
- Locations
- 🇳🇱
VU University Medical Center, Amsterdam, Noord-Holland, Netherlands
P3AMI Antiplatelet Trial
- First Posted Date
- 2015-03-03
- Last Posted Date
- 2020-02-10
- Lead Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
- Target Recruit Count
- 87
- Registration Number
- NCT02376283
- Locations
- 🇬🇧
The Royal Wolverhampton NHS Trust, Wolverhampton, West Midlands, United Kingdom
High "on Treatment" Platelet Reactivity in the Intensive Care Unit
- Conditions
- Interventions
- First Posted Date
- 2014-11-07
- Last Posted Date
- 2019-08-20
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 200
- Registration Number
- NCT02285751
- Locations
- 🇦🇹
General Hospital, Vienna, Austria
Ticagrelor and Endothelial Function
- Conditions
- Interventions
- First Posted Date
- 2014-10-10
- Last Posted Date
- 2014-10-10
- Lead Sponsor
- Hotel Dieu de France Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT02261922
- Locations
- 🇱🇧
Hotel Dieu de France Hospital, Achrafieh, Beirut, Lebanon
Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate
- Conditions
- Interventions
- First Posted Date
- 2014-09-17
- Last Posted Date
- 2014-09-17
- Lead Sponsor
- David Vivas
- Target Recruit Count
- 30
- Registration Number
- NCT02243137
- Locations
- 🇪🇸
Hospital Clínico San Carlos, Madrid, Spain
Sampling P2Y12 Receptor Inhibition With Prasugrel and Ticagrelor in Patients Submitted to Thrombolysis
- Conditions
- Interventions
- First Posted Date
- 2014-08-13
- Last Posted Date
- 2017-05-23
- Lead Sponsor
- Federal University of São Paulo
- Target Recruit Count
- 50
- Registration Number
- NCT02215993
- Locations
- 🇧🇷
Federal University of São Paulo, São Paulo, Brazil
Pharmacological Effects of Crushing Prasugrel in STEMI Patients
- First Posted Date
- 2014-08-08
- Last Posted Date
- 2016-12-28
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 52
- Registration Number
- NCT02212028
- Locations
- 🇺🇸
University of Florida, Jacksonville, Florida, United States
Clinical Trial to Characterize Pharmacokinetic-pharmacodynamic (PKPD) of Prasugrel 10 mg or 30 mg in Healthy Volunteers
- First Posted Date
- 2014-03-03
- Last Posted Date
- 2014-03-04
- Lead Sponsor
- Asan Medical Center
- Target Recruit Count
- 8
- Registration Number
- NCT02075268
- Locations
- 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of
A Pharmacodynamic Study Comparing Prasugrel Versus Ticagrelor in Patients Undergoing PCI With CYP2C19 Loss-of-function:
- First Posted Date
- 2014-02-19
- Last Posted Date
- 2020-09-16
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 65
- Registration Number
- NCT02065479
- Locations
- 🇺🇸
University of Florida, Jacksonville, Florida, United States
Drug Development Updates
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