Levothyroxine
- Generic Name
- Levothyroxine
- Brand Names
- Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid
- Drug Type
- Small Molecule
- Chemical Formula
- C15H11I4NO4
- CAS Number
- 51-48-9
- Unique Ingredient Identifier
- Q51BO43MG4
- Background
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...
- Indication
Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
- Associated Conditions
- Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer
- Associated Therapies
- -
Antithyroid Drug Treatment of Thyrotoxicosis in Young People
- Conditions
- Interventions
- First Posted Date
- 2011-09-20
- Last Posted Date
- 2016-09-21
- Lead Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
- Target Recruit Count
- 81
- Registration Number
- NCT01436994
- Locations
- 🇬🇧
Royal Hospital for Sick Children, Glasgow, United Kingdom
🇬🇧Hereford Hospital, Hereford, United Kingdom
🇬🇧St Bart's Hospital, London, United Kingdom
Sunitinib or Cediranib for Alveolar Soft Part Sarcoma
- Conditions
- Interventions
- First Posted Date
- 2011-07-12
- Last Posted Date
- 2023-11-29
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 34
- Registration Number
- NCT01391962
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
L-Thyroxine Supplementation for Preterm Newborns Less Than 32 Weeks of Gestation With Hypothyroxinemia
- First Posted Date
- 2011-03-01
- Last Posted Date
- 2018-08-10
- Lead Sponsor
- Centre Hospitalier Universitaire, Amiens
- Target Recruit Count
- 50
- Registration Number
- NCT01306227
- Locations
- 🇫🇷
Caen University Hospital, Caen, Basse Normandie, France
🇫🇷Lens Hospital, Lens, Nord- Pas De Calais, France
🇫🇷Amiens University Hospital, Amiens, Picardie, France
Central Hypothyroidism, a Novel Laboratory Measurement
- Conditions
- First Posted Date
- 2011-01-20
- Last Posted Date
- 2011-02-03
- Lead Sponsor
- Sheba Medical Center
- Target Recruit Count
- 50
- Registration Number
- NCT01280292
Levothyroxine in Pregnant SLE Patients
- First Posted Date
- 2011-01-13
- Last Posted Date
- 2015-09-10
- Lead Sponsor
- Johns Hopkins University
- Registration Number
- NCT01276782
- Locations
- 🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States
Levothyroxine (L-T4) Absorption After Bariatric Surgery
- First Posted Date
- 2010-08-26
- Last Posted Date
- 2010-08-26
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 30
- Registration Number
- NCT01189344
- Locations
- 🇧🇷
Hospital das Clínicas da Universidade de São Paulo, São Paulo, Brazil
Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively
- First Posted Date
- 2009-07-17
- Last Posted Date
- 2009-07-17
- Lead Sponsor
- Jagiellonian University
- Target Recruit Count
- 150
- Registration Number
- NCT00941551
- Locations
- 🇵🇱
Jagiellonian University, College of Medicine, Department of Endocrine Surgery, 3rd Chair of General Surgery, Krakow, Poland
Subclinical Hypothyroidism and Mind in the Elderly
- Conditions
- Interventions
- First Posted Date
- 2009-06-16
- Last Posted Date
- 2012-06-28
- Lead Sponsor
- Universidad Autonoma de Nuevo Leon
- Target Recruit Count
- 70
- Registration Number
- NCT00921050
- Locations
- 🇲🇽
Community Health Center (Fomerrey 19), Monterrey, Nuevo Leon, Mexico
🇲🇽Endocrinology, Outpatient Hospital Clinic, Monterrey, Nuevo Leon, Mexico
Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism
- First Posted Date
- 2008-10-09
- Last Posted Date
- 2010-10-26
- Lead Sponsor
- University of Aarhus
- Registration Number
- NCT00770016
- Locations
- 🇩🇰
Medical department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Sygehus,, Aarhus, Denmark
Combined Therapy With L-Thyroxine and L-Triiodothyronine Compared to L-Thyroxine Alone
- Conditions
- Interventions
- First Posted Date
- 2008-07-15
- Last Posted Date
- 2008-07-15
- Target Recruit Count
- 36
- Registration Number
- NCT00715572
Drug Development Updates
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