Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Sphenopalatine Ganglion Block for Management of Post- Dural Puncture Headache in Obstetric Patients

First Posted Date
2021-03-11
Last Posted Date
2022-02-16
Lead Sponsor
Ain Shams University
Target Recruit Count
40
Registration Number
NCT04793490
Locations
🇪🇬

Ain Shams University Hospital, Cairo, Abassia, Egypt

Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy

First Posted Date
2021-03-10
Last Posted Date
2024-08-16
Lead Sponsor
David Chi, MD
Target Recruit Count
73
Registration Number
NCT04791761
Locations
🇺🇸

UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States

Preemptive Analgesia With Celecoxib for Acute Dental Pain Management

First Posted Date
2021-03-10
Last Posted Date
2024-03-27
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
65
Registration Number
NCT04790812
Locations
🇺🇸

The University of Texas Health Science Center at Houston, Houston, Texas, United States

Usefulness of Acetaminophen Associated With Strong Opioids for Acute Pain in Cancer Patients

Phase 4
Completed
Conditions
Interventions
First Posted Date
2021-03-03
Last Posted Date
2021-08-13
Lead Sponsor
Pontificia Universidad Catolica de Chile
Target Recruit Count
112
Registration Number
NCT04779567
Locations
🇨🇱

Universidad Catolica de Chile, Santiago, Chile

Pre Emptive Analgesics for Pain Relief in Impacted Lower Third Molar Surgery

Phase 4
Completed
Conditions
Interventions
First Posted Date
2021-02-24
Last Posted Date
2021-02-24
Lead Sponsor
Melaka Manipal Medical College
Target Recruit Count
60
Registration Number
NCT04769557
Locations
🇲🇾

Melaka manipal medical college, Melaka, Malaysia

ESP in Breast Surgery Due to Cancer

First Posted Date
2021-01-27
Last Posted Date
2021-11-09
Lead Sponsor
Medical University of Lublin
Target Recruit Count
75
Registration Number
NCT04726878
Locations
🇵🇱

II Department of Anesthesia and Intensive Care, Medical University of Lublin, Lublin, Poland

OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients

First Posted Date
2021-01-05
Last Posted Date
2024-05-16
Lead Sponsor
Hersh, Elliot V., DMD, MS, PhD
Target Recruit Count
30
Registration Number
NCT04694300
Locations
🇺🇸

University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, United States

Detection of Paracetamol Concentration in Blood-, Saline- and Urine Samples - a Validation Study for a Novel Technique

First Posted Date
2020-12-31
Last Posted Date
2021-12-08
Lead Sponsor
Johanna Kujala
Target Recruit Count
12
Registration Number
NCT04690673
Locations
🇫🇮

Helsinki university hospital, Helsinki, Finland

Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis

First Posted Date
2020-12-30
Last Posted Date
2024-05-16
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
600
Registration Number
NCT04688788
Locations
🇩🇰

Department of Neurology, Herlev Hospital, Herlev, Denmark

🇩🇰

Department of Neurology, Aalborg University Hospital, Aalborg, Denmark

🇩🇰

Department of Neurology, Aarhus University Hospital, Aarhus, Denmark

and more 8 locations
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