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Papaverine

Generic Name
Papaverine
Drug Type
Small Molecule
Chemical Formula
C20H21NO4
CAS Number
58-74-2
Unique Ingredient Identifier
DAA13NKG2Q
Background

An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.

Indication

For the treatment of impotence and vasospasms.

Associated Conditions
Vascular spasm, Visceral spasms
Clinical Trials
Related News

Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

Phase 1
Recruiting
Conditions
Locally Advanced Rectal Adenocarcinoma
Stage II Rectal Cancer AJCC v8
Stage III Rectal Cancer AJCC v8
Interventions
Procedure: Biospecimen Collection
Procedure: Computed Tomography
Drug: Consolidation Therapy
Procedure: Functional Magnetic Resonance Imaging
Procedure: Gastrointestinal Endoscopy
Procedure: Magnetic Resonance Imaging
Radiation: Radiation Therapy
Procedure: Total Mesorectal Excision
First Posted Date
2025-02-19
Last Posted Date
2025-03-24
Lead Sponsor
City of Hope Medical Center
Target Recruit Count
36
Registration Number
NCT06834126
Locations
🇺🇸

City of Hope Medical Center, Duarte, California, United States

IV PAPAVERINE Prior to Propess for Labor Induction

Phase 4
Not yet recruiting
Conditions
Induced Vaginal Delivery
Interventions
Other: placebo
First Posted Date
2024-08-12
Last Posted Date
2024-08-12
Lead Sponsor
Western Galilee Hospital-Nahariya
Target Recruit Count
110
Registration Number
NCT06550232

Papaverine and Oxytocin vs Oxytocin Alone in Labor Induction

Not Applicable
Not yet recruiting
Conditions
Induced; Birth
Labor Onset and Length Abnormalities
Interventions
Drug: normal saline
First Posted Date
2024-08-09
Last Posted Date
2024-08-09
Lead Sponsor
Western Galilee Hospital-Nahariya
Target Recruit Count
126
Registration Number
NCT06547437

The Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cerebral Angiography

Phase 2
Recruiting
Conditions
Radial Artery Spasm
Interventions
Drug: normal saline
First Posted Date
2023-05-17
Last Posted Date
2023-06-12
Lead Sponsor
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Target Recruit Count
240
Registration Number
NCT05861765
Locations
🇨🇳

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Papaverine in Combination with Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

Phase 1
Recruiting
Conditions
Locally Advanced Lung Non-Small Cell Carcinoma
Stage II Lung Cancer AJCC V8
Stage IIA Lung Cancer AJCC V8
Stage IIB Lung Cancer AJCC V8
Stage III Lung Cancer AJCC V8
Stage IIIA Lung Cancer AJCC V8
Stage IIIB Lung Cancer AJCC V8
Stage IIIC Lung Cancer AJCC V8
Unresectable Lung Non-Small Cell Carcinoma
Interventions
Radiation: Radiation Therapy
First Posted Date
2021-11-29
Last Posted Date
2025-02-03
Lead Sponsor
Ohio State University Comprehensive Cancer Center
Target Recruit Count
28
Registration Number
NCT05136846
Locations
🇺🇸

City of Hope, Duarte, California, United States

🇺🇸

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Effect of Papaverine on Renal Artery Blood Flow Volume

Phase 4
Completed
Conditions
Kidney Cancer
Interventions
Drug: Normal saline
First Posted Date
2019-11-14
Last Posted Date
2021-04-19
Lead Sponsor
Asan Medical Center
Target Recruit Count
96
Registration Number
NCT04162834
Locations
🇰🇷

Asan medical Center, Seoul, Korea, Republic of

The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter

Early Phase 1
Completed
Conditions
Radial Artery Injury Prevetion
Interventions
Drug: xlyocaine
First Posted Date
2019-07-24
Last Posted Date
2020-09-16
Lead Sponsor
Kasr El Aini Hospital
Target Recruit Count
90
Registration Number
NCT04030663
Locations
🇪🇬

Faculty of Medicine, Cairo, Benisuef, Egypt

Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients

Phase 4
Completed
Conditions
Pediatrics
Anesthesia
Vasospasm
Interventions
Drug: Rescue papaverine, as needed
First Posted Date
2019-03-29
Last Posted Date
2022-10-27
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
100
Registration Number
NCT03894904
Locations
🇺🇸

UT Health, Houston, Texas, United States

Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases

Phase 1
Recruiting
Conditions
Lung Non-Small Cell Carcinoma
Interventions
Procedure: Blood Oxygen Level Dependent Imaging
Radiation: Stereotactic Body Radiation Therapy
First Posted Date
2019-01-31
Last Posted Date
2025-02-03
Lead Sponsor
Ohio State University Comprehensive Cancer Center
Target Recruit Count
24
Registration Number
NCT03824327
Locations
🇺🇸

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Prostatic Hyperplasia Treatment and Cancer Prevention

Early Phase 1
Conditions
Prostatic Hyperplasia
Interventions
Other: Placebo
First Posted Date
2017-02-27
Last Posted Date
2021-02-25
Lead Sponsor
Manchanda Medical Clinic
Target Recruit Count
40
Registration Number
NCT03064282
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