Metronidazole

Generic Name
Metronidazole
Brand Names
Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole
Drug Type
Small Molecule
Chemical Formula
C6H9N3O3
CAS Number
443-48-1
Unique Ingredient Identifier
140QMO216E
Background

Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.

Indication

Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, the heart, reproductive organs, central nervous system, and the respiratory system. Some may also be present in the bloodstream in cases of septicemia. Common infections treated by metronidazole are Bacteroides species infections, Clostridium infections, and Fusobacterium infections, as well as Peptococcus and Peptostreptococcus infections. Topical formulations of metronidazole are indicated for the treatment of inflammatory lesions of rosacea.

It is also used off-label in the treatment of Crohn's disease, as a prophylactic agent after surgery, and in the treatment of Helicobacter pylori infection. It has also been studied in the prevention of preterm births and to treat periodontal disease.

Associated Conditions
Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis
Associated Therapies
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Is it Effective to Treat Patients With Blastocystis Hominis Infection?

First Posted Date
2012-01-30
Last Posted Date
2022-08-23
Lead Sponsor
University of Lausanne Hospitals
Target Recruit Count
200
Registration Number
NCT01521403
Locations
🇨🇭

Travel Clinic, Department of Ambulatory Care and Community Medicine, University Hospital of Lausanne, Switzerland, Lausanne, Vaud, Switzerland

Compare Ceftazidime-Avibactam + Metronidazole Versus Meropenem for Hospitalized Adults With Complicated Intra-Abdominal Infections

First Posted Date
2011-12-26
Last Posted Date
2017-09-06
Lead Sponsor
Pfizer
Target Recruit Count
493
Registration Number
NCT01499290
Locations
🇺🇦

Research Site, Zaporizhzhya, Ukraine

A Phase 3 Study Of Intravenous Metronidazole For Intrabdominal Infection

First Posted Date
2011-11-17
Last Posted Date
2014-01-24
Lead Sponsor
Pfizer
Target Recruit Count
38
Registration Number
NCT01473836
Locations
🇯🇵

Iida Municipal Hospital, Iida, Nagano, Japan

🇯🇵

National Hospital Organization Kokura Medical Center, Kitakyushu, Fukuoka, Japan

🇯🇵

Koshigaya Municipal Hospital, Koshigaya, Saitama, Japan

and more 12 locations

Prospective Study of Clostridium Difficile in Children Undergoing Colonoscopy

Not Applicable
Withdrawn
Conditions
Interventions
First Posted Date
2011-11-17
Last Posted Date
2019-07-25
Lead Sponsor
State University of New York at Buffalo
Registration Number
NCT01472978
Locations
🇺🇸

Women and Children's Hospital, Buffalo, New York, United States

Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-08-31
Last Posted Date
2022-08-01
Lead Sponsor
Galderma R&D
Target Recruit Count
235
Registration Number
NCT01426269
Locations
🇺🇸

ATS Clinical Research, Santa Monica, California, United States

🇺🇸

Melissa L. F. Knuckles M.D., P.S.C., Richmond, Kentucky, United States

🇺🇸

Dadeland Dermatology, Coral Gables, Florida, United States

and more 7 locations

The Impact of Obesity on Nonsurgical Periodontal Therapy

First Posted Date
2011-07-29
Last Posted Date
2011-07-29
Lead Sponsor
Federal University of Rio Grande do Sul
Target Recruit Count
96
Registration Number
NCT01405365
Locations
🇧🇷

Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

Bioavailability Study of Metronidazole Capsules Under Fed Conditions

First Posted Date
2011-06-27
Last Posted Date
2011-06-27
Lead Sponsor
Par Pharmaceutical, Inc.
Target Recruit Count
18
Registration Number
NCT01380522
Locations
🇨🇦

Algorithme Pharma Inc, Montreal, Quebec, Canada

Bioavailability Study of Metronidazole Capsules Under Fasting Conditions

First Posted Date
2011-06-27
Last Posted Date
2011-06-27
Lead Sponsor
Par Pharmaceutical, Inc.
Target Recruit Count
28
Registration Number
NCT01380509
Locations
🇨🇦

Algorithme Pharma, Laval, Quebec, Canada

Study of How Bacterial Vaginosis and Its Treatment Affects Cervical and Vaginal Tissue

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-05-04
Last Posted Date
2017-12-19
Lead Sponsor
CONRAD
Target Recruit Count
35
Registration Number
NCT01347632
Locations
🇺🇸

Eastern Virginia Medical School CONRAD Clinical Research Center, Norfolk, Virginia, United States

Efficacy Study of Preconception Treatment of an Asymptomatic Bacterial Infection in an Infertility Population

First Posted Date
2011-03-25
Last Posted Date
2021-12-20
Lead Sponsor
Stanford University
Target Recruit Count
2
Registration Number
NCT01322971
Locations
🇺🇸

Ruth Lathi, Stanford, California, United States

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