Metronidazole

Generic Name: Metronidazole

Brand Names: Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole

Drug Type: Small Molecule

Chemical Formula: C_₆H_₉N_₃O_₃

CAS Number: 443-48-1

Unique Ingredient Identifier: 140QMO216E

Background: Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it ...

Indication: Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, t...

Associated Conditions: Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis

Associated Therapies: -

Clinical Trials

Non-invasive Test-guided Tailored Therapy Versus Empiric Treatment for Helicobacter Pylori Infection.

Phase 3

Conditions: Helicobacter Pylori Infection
Antibiotic Resistant Infection
Antibiotic Resistant Strain

Interventions: Drug: Pantoprazole 40mg
Drug: Amoxicillin 1000 MG
Drug: Clarithromycin 500mg
Drug: Metronidazole
Drug: Tetracycline 125 MG
Drug: Bismuth Subcitrate
Drug: Rifabutin 150 MG
Drug: Levofloxacin 500mg

First Posted Date: 2019-09-27

Last Posted Date: 2021-01-12

Lead Sponsor: University of Bari

Target Recruit Count: 362

Registration Number: NCT04107194

Locations: 🇮🇹
Michele Barone, Bari, BA, Italy

Evaluate the PK of Multiple Oral Doses of Tegoprazan, Metronidazole, Tetracycline and Bismuth in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Metronidazole
Drug: Tegoprazan
Drug: Tetracycline
Drug: Bismuth

First Posted Date: 2019-08-26

Last Posted Date: 2019-08-28

Lead Sponsor: HK inno.N Corporation

Target Recruit Count: 32

Registration Number: NCT04066257

Locations: 🇰🇷
Chonbuk National University Hospital, Jeonju, Korea, Republic of

High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori RescueTreatment

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Esomeprazole
Drug: Amoxicillin
Drug: Metronidazole

First Posted Date: 2019-07-18

Last Posted Date: 2021-09-28

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 306

Registration Number: NCT04024527

Locations: 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China

Metronidazole vs Placebo as Adjuncts to Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis

Not Applicable

Completed

Conditions: Periodontitis
Surgery

Interventions: Drug: Placebo
Drug: Metronidazole
Procedure: periodontal surgery

First Posted Date: 2019-03-19

Last Posted Date: 2019-03-20

Lead Sponsor: Universidad Complutense de Madrid

Target Recruit Count: 17

Registration Number: NCT03880448

Locations: 🇪🇸
Faculty of Dentistry, University Complutense, Madrid, Spain

Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar Surgery

Not Applicable

Conditions: Infection

Interventions: Drug: Co-Amoxiclav
Drug: Paracetamol
Drug: Chlorhexidine mouthwash
Drug: Normal saline
Drug: Amoxicillin 500 Mg
Drug: Metronidazole

First Posted Date: 2019-02-18

Last Posted Date: 2020-10-06

Lead Sponsor: Taibah University

Target Recruit Count: 135

Registration Number: NCT03844776

Locations: 🇸🇦
Taibah University, Medina, Saudi Arabia

Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015)

Phase 3

Completed

Conditions: Complicated Intra-abdominal Infections

Interventions: Drug: Ceftolozane/Tazobactam
Drug: Meropenem
Drug: Placebo
Drug: Metronidazole

First Posted Date: 2019-02-05

Last Posted Date: 2023-01-17

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 268

Registration Number: NCT03830333

Locations: 🇨🇳
Wuxi No.2 People's Hospital ( Site 0050), Wuxi, Jiangsu, China
🇨🇳
Navy General Hospital ( Site 0009), Beijing, Beijing, China
🇨🇳
The First Affiliated Hospital of Guangzhou Medical University ( Site 0026), Guangzhou, Guangdong, China

and more 22 locations