Quinine

Generic Name: Quinine

Brand Names: Qualaquin

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₄N_₂O_₂

CAS Number: 130-95-0

Unique Ingredient Identifier: A7V27PHC7A

Background: An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.

Indication: For the treatment of malaria and leg cramps

Associated Conditions: Uncomplicated Malaria caused by Plasmodium falciparum

Associated Therapies: -

Clinical Trials

Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa

Phase 3

Completed

Conditions: Drug Resistant Malaria Due to Plasmodium Falciparum

Interventions: Drug: Dihydroartemisinin piperaquine
Drug: Artesunate mefloquine
Drug: Arthemeter-lumefantrine
Drug: Paracetamol
Drug: Amoxicillin
Drug: Quinine

First Posted Date: 2016-11-28

Last Posted Date: 2016-11-29

Lead Sponsor: University of Bamenda

Target Recruit Count: 300

Registration Number: NCT02974348

Locations: 🇨🇲
CDC Hospital, Tiko, South west, Cameroon

A Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - Cameroon

Phase 3

Completed

Conditions: Malaria

Interventions: Drug: Artesunate
Drug: Quinine

First Posted Date: 2015-09-30

Last Posted Date: 2015-10-01

Lead Sponsor: University of Yaounde 1

Target Recruit Count: 238

Registration Number: NCT02563704

Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain

Phase 2

Withdrawn

Conditions: Compliance
Chronic Pain

Interventions: Drug: acetazolamide
Drug: Quinine
Drug: Riboflavin

First Posted Date: 2014-10-28

Last Posted Date: 2017-02-10

Lead Sponsor: Georgetown University

Registration Number: NCT02276989

Locations: 🇺🇸
Georgetown University, Washington, District of Columbia, United States

Parenteral Artesunate Compared to Quinine as a Cause of Late Anaemia in African Children With Malaria

Phase 4

Completed

Conditions: Anaemia

Interventions: Drug: artesunate
Drug: quinine

First Posted Date: 2014-03-20

Last Posted Date: 2015-06-01

Lead Sponsor: University of Oxford

Target Recruit Count: 217

Registration Number: NCT02092766

Locations: 🇨🇩
Kinshasa School of Public Health, Kinshasa, Congo, The Democratic Republic of the

Interactions Between Intravenous Cocaine and Acetazolamide or Quinine

Phase 1

Completed

Conditions: Cocaine Use
Pharmacokinetics

First Posted Date: 2013-05-10

Last Posted Date: 2018-07-05

Lead Sponsor: National Institute on Drug Abuse (NIDA)

Target Recruit Count: 14

Registration Number: NCT01851473

Locations: 🇺🇸
National Institute on Drug Abuse, Baltimore, Maryland, United States

Intravenous Artesunate and Malaria

Phase 4

Conditions: Malaria

Interventions: Drug: artesunate
Drug: Quinine

First Posted Date: 2013-03-06

Last Posted Date: 2013-03-06

Lead Sponsor: University of Khartoum

Target Recruit Count: 80

Registration Number: NCT01805232

Locations: 🇸🇩
Kassala, Kassala, Sudan

Superiority of ArTiMist Versus Quinine in Children With Severe Malaria

Phase 3

Completed

Conditions: Plasmodium Falciparum Malaria

Interventions: Drug: Quinine
Drug: Artemether Sublingual Spray

First Posted Date: 2010-12-10

Last Posted Date: 2014-02-28

Lead Sponsor: Proto Pharma Ltd

Target Recruit Count: 151

Registration Number: NCT01258049

Locations: 🇷🇼
Rwinkwavu District Hospital, Rwinkwavu, Eastern Province, Rwanda
🇬🇭
Navrongo Health Research Centre, Navrongo, Ghana
🇧🇫
Centre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso