Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014, becoming the first approved therapy against PD-1. In the time since its initial approval, pembrolizumab has been granted approval in the treatment of a wide variety of cancers.
Pembrolizumab is indicated for the following conditions:
For all approved adult indications, pembrolizumab may be used for an additional 6 weeks at 400mg weekly.
Providence Cancer Center, Portland, Oregon, United States
Gabrail Cancer Center Research, Canton, Ohio, United States
John Wayne Cancer Institute, Santa Monica, California, United States
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Virginia Cancer Specialists, PC, Fairfax, Virginia, United States
Gabrail Cancer Center, Canton, Ohio, United States
University of Chicago, Chicago, Illinois, United States
LungenClinic Grosshansdorf, Großhansdorf, Germany
Royal Marsden, London, United Kingdom
NIHR Biomedical Research Centre at RM and ICR (https://www.cancerbrc.org/), Sutton, United Kingdom
MD Anderson Cancer Center, Houston, Texas, United States
Moffitt Cancer Center, Tampa, Florida, United States
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
Northwestern University, Robert H. Lurie Cancer Center, Chicago, Illinois, United States
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States
Palo Verde Hematology Oncology, Glendale, Arizona, United States
UCLA Hematology Oncology, Los Angeles, California, United States
Georgetown University Medical Center, Washington, District of Columbia, United States
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