Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
- -
Diclofenac add-on to Treatment as Usual for Suicidal Patients
- First Posted Date
- 2011-08-10
- Last Posted Date
- 2019-01-10
- Lead Sponsor
- Region Skane
- Registration Number
- NCT01413854
- Locations
- 🇸🇪
Psychiatry Skane, Lund, Sweden
Topical Vitamin D3, Diclofenac or a Combination of Both to Treat Basal Cell Carcinoma
- Conditions
- Interventions
- First Posted Date
- 2011-05-23
- Last Posted Date
- 2015-01-13
- Lead Sponsor
- Maastricht University Medical Center
- Target Recruit Count
- 128
- Registration Number
- NCT01358045
- Locations
- 🇳🇱
Maastricht University Medical Center, Maastricht, Limburg, Netherlands
Efficacy of PENNSAID® for Pain Management in the Emergency Department
- Conditions
- Interventions
- First Posted Date
- 2011-05-10
- Last Posted Date
- 2016-12-21
- Lead Sponsor
- University of Utah
- Registration Number
- NCT01350622
- Locations
- 🇺🇸
University of Utah, Salt Lake City, Utah, United States
Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Ankle Sprain
- First Posted Date
- 2011-01-10
- Last Posted Date
- 2013-01-24
- Lead Sponsor
- Novartis
- Target Recruit Count
- 205
- Registration Number
- NCT01272934
- Locations
- 🇩🇪
NCH investigative site, Gilching, Germany
🇩🇪NCH investigative site, Munich, Germany., Munich, Germany
Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Blunt Trauma Injuries
- Conditions
- Interventions
- First Posted Date
- 2011-01-10
- Last Posted Date
- 2013-01-10
- Lead Sponsor
- Novartis
- Target Recruit Count
- 204
- Registration Number
- NCT01272947
- Locations
- 🇩🇪
NCH investigative site, Munich, Germany
Efficacy of Diclofenac Potassium vs Nimesulide in the Treatment of Fever and Pain in Children With Upper Respiratory Tract Infection
- Conditions
- Interventions
- First Posted Date
- 2010-12-09
- Last Posted Date
- 2012-04-26
- Lead Sponsor
- Novartis Pharmaceuticals
- Registration Number
- NCT01257126
Microcirculation & ASICs
- Conditions
- First Posted Date
- 2010-11-23
- Last Posted Date
- 2019-05-28
- Lead Sponsor
- Hospices Civils de Lyon
- Target Recruit Count
- 20
- Registration Number
- NCT01246180
- Locations
- 🇫🇷
Pôle d'activité medicale-Centre Hospitalier Lyon Sud-Hospices Civils de Lyon, Pierre Bénite, France
Use of Etoricoxib Compared to Diclofenac in the Perioperative Treatment of Patients After Total Hip Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2010-10-28
- Last Posted Date
- 2014-09-15
- Lead Sponsor
- University of Regensburg
- Target Recruit Count
- 100
- Registration Number
- NCT01229774
- Locations
- 🇩🇪
Department of Orthopedic Surgery, Bad Abbach, Bavaria, Germany
A Study Comparing Etoricoxib and Diclofenac Sodium in Post Hallux Valgus Surgery Pain
- Conditions
- Interventions
- First Posted Date
- 2010-08-30
- Last Posted Date
- 2017-12-02
- Lead Sponsor
- Karolinska Institutet
- Registration Number
- NCT01190722
Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA)
- First Posted Date
- 2010-02-11
- Last Posted Date
- 2021-06-23
- Lead Sponsor
- Northumbria Healthcare NHS Foundation Trust
- Registration Number
- NCT01067430
- Locations
- 🇬🇧
Northumbria Healthcare NHS Foundation Trust, North Shields, Tyne And Wear, United Kingdom
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.