Diclofenac

Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of phenylbutazone, mefenamic acid, and indomethacin. The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with misoprostol to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren, marketed by Novartis (previously Ciba-Geigy).

Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of phenylbutazone, mefenamic acid, and indomethacin. The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with misoprostol to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren, marketed by Novartis (previously Ciba-Geigy).

Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in patients with high risk of developing NSAID-induced ulcers.

• Actinic Keratosis (AK)
• Acute Arthritis
• Acute Gouty Arthritis
• Acute Migraine
• Acute Musculoskeletal Pain
• Ankylosing Spondylitis (AS)
• Common Cold
• Fever
• Gout
• Inflammation
• Inflammatory Disease of the Oral Cavity
• Inflammatory Disease of the throat
• Inflammatory Reaction of the Nerve
• Joint Pain
• Juvenile Idiopathic Arthritis (JIA)
• Menstrual Distress (Dysmenorrhea)
• Muscle Inflammation
• Myalgia
• Neuropathic Pain
• Ocular Inflammation
• Osteoarthritis (OA)
• Osteoarthritis of the Knee
• Pain
• Pain caused by Rheumatism
• Pericarditis
• Photophobia
• Postoperative Inflammatory Response
• Postoperative pain
• Primary Dysmenorrhoea
• Radicular Pain
• Rheumatism
• Rheumatoid Arthritis
• Seasonal Allergic Conjunctivitis
• Spinal pain
• Tendon pain
• Vertebral column pain
• Acute Musculoskeletal injury
• Acute, moderate, severe Pain, Inflammatory
• Localized soft tissue rheumatism
• Mild to moderate joint pain
• Mild to moderate pain
• Minor pain
• Perioperative miosis