MedPath

PL-0264

Generic Name
PL-0264

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

Phase 1
Recruiting
Conditions
Glioma
Medulloblastoma
Ependymoma
Interventions
First Posted Date
2023-12-08
Last Posted Date
2025-03-25
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
120
Registration Number
NCT06161519
Locations
🇺🇸

National Institutes of Health Clinical Center, Bethesda, Maryland, United States

A Study to Evaluate the Efficacy and Toxicities of PLX038, in Patients With Locally Advanced or Metastatic Triple-negative Breast Cancer

Phase 2
Recruiting
Conditions
Breast
Cancer
Interventions
First Posted Date
2023-12-08
Last Posted Date
2024-10-07
Lead Sponsor
Institut Curie
Target Recruit Count
44
Registration Number
NCT06162351
Locations
🇫🇷

Institut Curie, Saint Cloud, France

PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell Cancers

Phase 1
Completed
Conditions
Small Cell Lung Cancer
Extra-Pulmonary Small Cell Carcinomas
Interventions
First Posted Date
2019-12-24
Last Posted Date
2025-03-17
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
10
Registration Number
NCT04209595
Locations
🇺🇸

National Institutes of Health Clinical Center, Bethesda, Maryland, United States

A Phase I Study of PLX038 in Patients With Advanced Solid Tumors

Phase 1
Completed
Conditions
Cancer
Tumors
Neoplasms
Interventions
First Posted Date
2016-01-06
Last Posted Date
2023-07-12
Lead Sponsor
ProLynx LLC
Target Recruit Count
40
Registration Number
NCT02646852
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

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