A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
Bristol - Myers Squibb Co, Wallingford, Connecticut, United States
Centre Hospitalier de la Universite de Montreal (CHUM), Montreal, Quebec, Canada
Centre de traitment d'immunodeficience, Montreal, Quebec, Canada
Viridae Clinical Sciences / University of British Columbia, Vancouver, British Columbia, Canada
Northwestern Univ Med School, Chicago, Illinois, United States
UCLA Med Ctr / Pediatric, Los Angeles, California, United States
Johns Hopkins Hosp, Baltimore, Maryland, United States
St Paul Ramsey Med Ctr, Saint Paul, Minnesota, United States
Adirondack Med Ctr at Saranac Lake, Albany, New York, United States
Mid - Hudson Care Ctr, Albany, New York, United States
USC CRS, Los Angeles, California, United States
Ucsf Aids Crs, San Francisco, California, United States
UCLA CARE Center CRS, Los Angeles, California, United States
Connecticut Children's Med Ctr, Farmington, Connecticut, United States
Cedars Sinai / UCLA Med Ctr, Los Angeles, California, United States
Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States
Spedali Civili - Carosi, Brescia, Italy
Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States
Univ of Southern California / LA County USC Med Ctr, Los Angeles, California, United States
Children's Med Ctr of Dallas, Dallas, Texas, United States
Univ of Maryland at Baltimore / Univ Med Ctr, Baltimore, Maryland, United States
UCLA Med Ctr / Pediatric, Los Angeles, California, United States
Cook County Hosp, Chicago, Illinois, United States
Univ of Massachusetts Med School, Worcester, Massachusetts, United States
Univ of Mississippi Med Ctr, Jackson, Mississippi, United States
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