Dobutamine

Generic Name: Dobutamine

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₃NO_₃

CAS Number: 34368-04-2

Unique Ingredient Identifier: 3S12J47372

Background: A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.

Indication: Indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.

Associated Conditions: Cardiac Decompensation, Coronary Artery Disease (CAD)

Associated Therapies: Intravenous inotropic therapy

Clinical Trials

Dobutamine on the Cardiac Conduction System

Early Phase 1

Completed

Conditions: Arrhythmias, Cardiac

Interventions: Drug: Dobutamine

First Posted Date: 2020-01-30

Last Posted Date: 2022-01-26

Lead Sponsor: Northwell Health

Target Recruit Count: 37

Registration Number: NCT04249258

Locations: 🇺🇸
Long Island Jewish Hospital, New Hyde Park, New York, United States

Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion

Phase 3

Recruiting

Conditions: Sepsis
Cardiomyopathies
Hypoperfusion
Left Ventricular Systolic Dysfunction

Interventions: Drug: Placebos
Drug: Dobutamine

First Posted Date: 2019-11-18

Last Posted Date: 2023-12-12

Lead Sponsor: University Hospital, Limoges

Target Recruit Count: 270

Registration Number: NCT04166331

Locations: 🇫🇷
Angouleme Hospital, Angoulême, France
🇫🇷
CH de Vendée, La Roche-sur-Yon, France
🇫🇷
CH de Cannes, Cannes, France

and more 23 locations

Improving Tissue Oxygenation in Breast Reconstruction Surgery

Phase 1

Recruiting

Conditions: Perioperative Tissue Oxygenation

Interventions: Drug: Dobutamine

First Posted Date: 2019-07-15

Last Posted Date: 2024-04-04

Lead Sponsor: Dr. Glenio Mizubuti (MD, MSc)

Target Recruit Count: 40

Registration Number: NCT04020172

Locations: 🇨🇦
Hotel Dieu Hospital, Kingston, Ontario, Canada
🇨🇦
Kingston General Hospital, Kingston, Ontario, Canada

Influence of Continuous Administration of Phenylephrine Versus Dobutamine on Spinal Oxygen Saturation, Measured With Near-infrared Spectroscopy (NIRS).

Phase 4

Completed

Conditions: Nfuence of Vasoactive Medication on Spinal Oxygenation

Interventions: Drug: Phenylephrine
Drug: Dobutamine

First Posted Date: 2019-02-20

Last Posted Date: 2022-12-12

Lead Sponsor: University Hospital, Ghent

Target Recruit Count: 36

Registration Number: NCT03846765

Locations: 🇧🇪
Ghent University Hospital, Ghent, Belgium

Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period

Phase 1

Terminated

Conditions: Shock

Interventions: Drug: Dobutamine

First Posted Date: 2017-10-17

Last Posted Date: 2017-10-17

Lead Sponsor: Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz

Target Recruit Count: 15

Registration Number: NCT03311178

Locations: 🇪🇸
La Paz University Hospital, Department of Neonatology, Madrid, Spain

Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps

Not Applicable

Completed

Conditions: Optimal Tissue Perfusion

Interventions: Other: Fluid management
Drug: Norepinephrine
Drug: Dobutamine

First Posted Date: 2017-09-19

Last Posted Date: 2019-05-15

Lead Sponsor: Szeged University

Target Recruit Count: 30

Registration Number: NCT03288051

Locations: 🇭🇺
Department of Anaesthesiology and Intensive Therapy, Szeged, Csongrád, Hungary

Milrinone Versus Dobutamine in Critically Ill Patients

Phase 4

Completed

Conditions: Acute Coronary Syndrome
Low Cardiac Output Syndrome
Cardiogenic Shock
Pulmonary Edema

Interventions: Drug: Milrinone
Drug: Dobutamine

First Posted Date: 2017-07-02

Last Posted Date: 2020-06-30

Lead Sponsor: Ottawa Heart Institute Research Corporation

Target Recruit Count: 192

Registration Number: NCT03207165

Locations: 🇨🇦
University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock

Not Applicable

Conditions: Septic Shock

Interventions: Device: Microdialysis Probe (Muscle microdialysis)
Drug: Levosimendan
Drug: Dobutamine

First Posted Date: 2016-11-15

Last Posted Date: 2018-02-12

Lead Sponsor: Military Hospital of Tunis

Target Recruit Count: 50

Registration Number: NCT02963454

Locations: 🇹🇳
Military Hopital of Tunis, Tunis, Tunisia

Haemodynamic Effects of Dobutamine and Nitrite in LV Dysfunction

Conditions: Heart Failure

First Posted Date: 2016-09-05

Last Posted Date: 2016-09-05

Lead Sponsor: King's College London

Target Recruit Count: 45

Registration Number: NCT02888561

Locations: 🇬🇧
British Heart Foundation Centre of Excellence, The Rayne Institute, KCL, at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure

Phase 4

Withdrawn

Conditions: Acute Heart Failure

Interventions: Drug: Sodium nitroprusside
Drug: Dobutamine
Drug: Furosemide

First Posted Date: 2016-05-10

Last Posted Date: 2018-10-31

Lead Sponsor: Montefiore Medical Center

Registration Number: NCT02767024

Locations: 🇺🇸
Montefiore Medical Center, Bronx, New York, United States

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