DeepMed Research

Dobutamine

Generic Name: Dobutamine

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₃NO_₃

CAS Number: 34368-04-2

Unique Ingredient Identifier: 3S12J47372

Background: A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.

Indication: Indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.

Associated Conditions: Cardiac Decompensation, Coronary Artery Disease (CAD)

Associated Therapies: Intravenous inotropic therapy

Clinical Trials

Dobutamine for Management of Surgical Patients with Septic Shock

Not Applicable

Recruiting

Conditions: Patients with Septic Shock
Surgical Patients
General Anesthesia

Interventions: Drug: Norepinephrine
Drug: Dobutamine

First Posted Date: 2024-06-17

Last Posted Date: 2024-12-04

Lead Sponsor: First Affiliated Hospital of Zhejiang University

Target Recruit Count: 584

Registration Number: NCT06462313

Locations: 🇨🇳
The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Haemodynamic Effects of Dobutamine in Patients With Wild-type Transthyretin Amyloid Cardiomyopathy (ATTRwt)

Phase 1

Recruiting

Conditions: ATTR Amyloidosis Wild Type

Interventions: Drug: Dobutrex

First Posted Date: 2024-03-19

Last Posted Date: 2024-04-17

Lead Sponsor: Steen Hvitfeldt Poulsen

Target Recruit Count: 35

Registration Number: NCT06318260

Locations: 🇩🇰
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark

Effect of TEE-guided Non-fluid Limited Combined With Dobutamine on Hepatic Venous Blood Flow Spectrum

Early Phase 1

Not yet recruiting

Conditions: Laparoscopic Hepatectomy

Interventions: Drug: Dobutamine hydrochloride, Injectable
Drug: 0.9% normal saline

First Posted Date: 2024-01-18

Last Posted Date: 2024-01-18

Lead Sponsor: Sichuan University

Target Recruit Count: 51

Registration Number: NCT06210217

Locations: 🇨🇳
West China Hospital, Chengdu, Sichuan, China

Dobutamine Versus Milrinone in Management of Critically Ill Low Cardiac Output Pediatric Patients at Cairo University Children's Hospital

Not Applicable

Not yet recruiting

Conditions: Dobutamine, Milrinone , Pediatrics , Low Cardiac Output

Interventions: Drug: Dobutamine

First Posted Date: 2023-08-21

Last Posted Date: 2023-08-21

Lead Sponsor: Cairo University

Target Recruit Count: 40

Registration Number: NCT05999487

Locations: 🇪🇬
Cairo University Children'S Hospital, Giza, Egypt

Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation.

Phase 2

Not yet recruiting

Conditions: Hyperlactatemia
Sepsis
Hypoperfusion

Interventions: Drug: Dobutamine

First Posted Date: 2023-07-19

Last Posted Date: 2024-01-30

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 120

Registration Number: NCT05953142

Locations: 🇧🇷
Federal University of São Paulo, São Paulo, Brazil

Consistency of Carotid Doppler Blood Flow and Thermodilution Technique

Not Applicable

Recruiting

Conditions: Cardiac Surgery

Interventions: Behavioral: passive leg raising
Drug: Dobutamine

First Posted Date: 2023-07-13

Last Posted Date: 2023-07-13

Lead Sponsor: Shanghai Zhongshan Hospital

Target Recruit Count: 200

Registration Number: NCT05944146

Locations: 🇨🇳
Zhongshan hospital Fudan University, Shanghai, Shanghai, China

Right Ventricular Contractile Reserve in HF

Not Applicable

Recruiting

Conditions: Heart Failure

Interventions: Drug: Dobutamine
Other: Passive leg raising

First Posted Date: 2023-04-04

Last Posted Date: 2023-04-04

Lead Sponsor: Istituto Auxologico Italiano

Target Recruit Count: 60

Registration Number: NCT05797584

Locations: 🇮🇹
Ospedale San Luca IRCCS Istituto Auxologico Italiano, Milan, MI, Italy

Ivabradine Effects in Cardiogenic Shock Requiring Inotropic Support

Phase 3

Recruiting

Conditions: Ischemic Heart Disease
Cardiogenic Shock
Heart Failure

Interventions: Drug: DOBUTamine Injectable Solution
Drug: Ivabradine 7.5Mg Tab

First Posted Date: 2022-10-26

Last Posted Date: 2022-10-26

Lead Sponsor: The Young Investigator Group of Cardiovascular Research

Target Recruit Count: 200

Registration Number: NCT05594342

Locations: 🇪🇬
Andalusia Hospitals, Alexandria, Egypt
🇪🇬
Tiba Hospital, Alexandria, Egypt

Consistency of Electrical Cardiometry and Pulmonary Artery Catheter

Not Applicable

Recruiting

Conditions: Right Ventricular Dysfunction
Pulmonary Arterial Hypertension

Interventions: Behavioral: passive leg raising
Drug: dobutamine test
Drug: inhaled nitric oxide

First Posted Date: 2022-10-20

Last Posted Date: 2022-10-20

Lead Sponsor: Shanghai Zhongshan Hospital

Target Recruit Count: 199

Registration Number: NCT05587400

Locations: 🇨🇳
Zhongshan hospital Fudan University, Shanghai, Shanghai, China

Low-Dose Dobutamine and Single-Dose Tocilizumab in Acute Myocardial Infarction With High Risk of Cardiogenic Shock

Phase 2

Recruiting

Conditions: Cardiogenic Shock
Acute Myocardial Infarction

Interventions: Drug: Tocilizumab
Drug: Dobutamine
Drug: NaCl 0.9%

First Posted Date: 2022-04-28

Last Posted Date: 2024-11-26

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 100

Registration Number: NCT05350592

Locations: 🇩🇰
Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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