DeepMed Research

Dobutamine

Generic Name: Dobutamine

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₃NO_₃

CAS Number: 34368-04-2

Unique Ingredient Identifier: 3S12J47372

Background: A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.

Indication: Indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.

Associated Conditions: Cardiac Decompensation, Coronary Artery Disease (CAD)

Associated Therapies: Intravenous inotropic therapy

Clinical Trials

Liberal Versus Restrictive Use of Dobutamine in Cardiac Surgery

Phase 3

Completed

Conditions: Cardiac Output, Low
Coronary Disease

Interventions: Drug: Liberal dobutamine protocol
Drug: Restrictive dobutamine protocol

First Posted Date: 2015-02-12

Last Posted Date: 2022-03-16

Lead Sponsor: University of Sao Paulo

Target Recruit Count: 160

Registration Number: NCT02361801

Locations: 🇧🇷
Heart Institute, Sao Paulo, SP, Brazil

Levosimendan Versus Dobutamine for Renal Function in Heart Failure

Phase 3

Completed

Conditions: Cardiorenal Syndrome

Interventions: Drug: Levosimendan
Drug: Dobutamine

First Posted Date: 2014-05-07

Last Posted Date: 2020-02-25

Lead Sponsor: Göteborg University

Target Recruit Count: 33

Registration Number: NCT02133105

Locations: 🇸🇪
Sahlgrenska University Hospital, Gothenburg, Sweden

NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy

Completed

Conditions: Circulatory Failure

Interventions: Drug: Dobutamine

First Posted Date: 2014-01-31

Last Posted Date: 2016-09-05

Lead Sponsor: Brighton and Sussex University Hospitals NHS Trust

Target Recruit Count: 18

Registration Number: NCT02051894

Locations: 🇬🇧
Trevor Mann Baby Unit, Brighton, Sussex, United Kingdom

Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury

Phase 2

Conditions: Severe Traumatic Brain Injury With High Cerebral Pressure

Interventions: Drug: Norepinephrine
Drug: Dobutamine and norepinephrine

First Posted Date: 2013-12-24

Last Posted Date: 2015-08-17

Lead Sponsor: University Hospital, Grenoble

Target Recruit Count: 20

Registration Number: NCT02019810

Locations: 🇫🇷
Grenoble University Hospital, Grenoble, France

Levosimendan Versus Dobutamine in Cardiopatic Patients Undergoing Major Non Cardiac Surgery

Phase 4

Conditions: Cardiovascular Diseases

Interventions: Drug: Dobutamine
Drug: Levosimendan

First Posted Date: 2013-12-17

Last Posted Date: 2013-12-17

Lead Sponsor: Azienda Policlinico Umberto I

Target Recruit Count: 40

Registration Number: NCT02012946

Locations: 🇮🇹
Francesco Pugliese, Rome, Italy

The Effects of Levosimendan During Mitral Valve Surgery

Phase 4

Completed

Conditions: Mitral Valve Stenosis With Incompetence or Regurgitation

Interventions: Drug: Levosimendan
Drug: Dobutamine

First Posted Date: 2013-10-25

Last Posted Date: 2013-10-25

Lead Sponsor: Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital

Target Recruit Count: 140

Registration Number: NCT01969071

Locations: 🇹🇷
Kartal Kosuyolu High Speciality Training and Research Hospital, Istanbul, Turkey

Outcome and Safety of Intermittent Dobutamine Infusion at a Day-Care Center in Advanced Heart Failure Patients

Phase 4

Conditions: Heart Failure

Interventions: Drug: Normal Saline
Drug: Dobutamine

First Posted Date: 2013-08-29

Last Posted Date: 2013-08-30

Lead Sponsor: Sheba Medical Center

Target Recruit Count: 60

Registration Number: NCT01930734

Locations: 🇮🇱
Leviev Heart Center, Chaim Sheba Medical Center, Ramat-Gan, Israel

Dobutamine Versus Placebo for Low Superior Vena Cava Flow in Newborns

Phase 2

Completed

Conditions: Hemodynamic Instability

Interventions: Drug: Placebo
Drug: Dobutamine

First Posted Date: 2012-05-24

Last Posted Date: 2015-03-09

Lead Sponsor: Adelina Pellicer

Target Recruit Count: 127

Registration Number: NCT01605279

Locations: 🇪🇸
La Paz University Hospital, Madrid, Spain

Dopamine Versus Dobutamine for Treatment of Arterial Hypotension in Term and Preterm Neonates

Phase 4

Conditions: Arterial Hypotension

Interventions: Drug: Dobutamine
Drug: Dopamine

First Posted Date: 2011-09-01

Last Posted Date: 2016-04-06

Lead Sponsor: University of Ulm

Target Recruit Count: 20

Registration Number: NCT01427686

Locations: 🇩🇪
University Medical Center, Ulm University, Ulm, Baden-Württemberg, Germany

Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery

Phase 4

Completed

Conditions: Oral Cancer
Head and Neck Cancer
Free Flap
Hypotension

Interventions: Drug: Epinephrine
Drug: Norepinephrine
Drug: Dobutamine
Drug: Dopexamine

First Posted Date: 2011-08-16

Last Posted Date: 2011-08-16

Lead Sponsor: Oxford University Hospitals NHS Trust

Target Recruit Count: 25

Registration Number: NCT01418118

Locations: 🇬🇧
John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom

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