MedPath

Dobutamine

Generic Name
Dobutamine
Drug Type
Small Molecule
Chemical Formula
C18H23NO3
CAS Number
34368-04-2
Unique Ingredient Identifier
3S12J47372
Background

A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.

Indication

Indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.

Associated Conditions
Cardiac Decompensation, Coronary Artery Disease (CAD)
Associated Therapies
Intravenous inotropic therapy
Clinical Trials
Related News

Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps

Not Applicable
Completed
Conditions
Optimal Tissue Perfusion
Interventions
Other: Fluid management
First Posted Date
2017-09-19
Last Posted Date
2019-05-15
Lead Sponsor
Szeged University
Target Recruit Count
30
Registration Number
NCT03288051
Locations
🇭🇺

Department of Anaesthesiology and Intensive Therapy, Szeged, Csongrád, Hungary

Milrinone Versus Dobutamine in Critically Ill Patients

Phase 4
Completed
Conditions
Acute Coronary Syndrome
Low Cardiac Output Syndrome
Cardiogenic Shock
Pulmonary Edema
Interventions
First Posted Date
2017-07-02
Last Posted Date
2020-06-30
Lead Sponsor
Ottawa Heart Institute Research Corporation
Target Recruit Count
192
Registration Number
NCT03207165
Locations
🇨🇦

University of Ottawa Heart Institute, Ottawa, Ontario, Canada

A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems

Phase 1
Terminated
Conditions
Drug-Related Side Effects and Adverse Reactions
Cardiovascular System Disease
Interventions
Drug: Placebo
First Posted Date
2017-04-04
Last Posted Date
2021-03-22
Lead Sponsor
Cambridge University Hospitals NHS Foundation Trust
Target Recruit Count
18
Registration Number
NCT03098680
Locations
🇬🇧

Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock

Not Applicable
Conditions
Septic Shock
Interventions
Device: Microdialysis Probe (Muscle microdialysis)
First Posted Date
2016-11-15
Last Posted Date
2018-02-12
Lead Sponsor
Military Hospital of Tunis
Target Recruit Count
50
Registration Number
NCT02963454
Locations
🇹🇳

Military Hopital of Tunis, Tunis, Tunisia

Haemodynamic Effects of Dobutamine and Nitrite in LV Dysfunction

Conditions
Heart Failure
First Posted Date
2016-09-05
Last Posted Date
2016-09-05
Lead Sponsor
King's College London
Target Recruit Count
45
Registration Number
NCT02888561
Locations
🇬🇧

British Heart Foundation Centre of Excellence, The Rayne Institute, KCL, at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure

Phase 4
Withdrawn
Conditions
Acute Heart Failure
Interventions
First Posted Date
2016-05-10
Last Posted Date
2018-10-31
Lead Sponsor
Montefiore Medical Center
Registration Number
NCT02767024
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Decision Support for Intraoperative Low Blood Pressure

Not Applicable
Completed
Conditions
Hypotension
Interventions
Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Packed Red Blood Cells
Drug: Albumin solutions
First Posted Date
2016-04-04
Last Posted Date
2019-05-16
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
22435
Registration Number
NCT02726620
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Dobutamaine Versus Milrinone in Cardiorenal Syndrome

Phase 2
Withdrawn
Conditions
Cardiorenal Syndrome
Interventions
First Posted Date
2015-12-31
Last Posted Date
2018-08-10
Lead Sponsor
Maimonides Medical Center
Registration Number
NCT02644057
Locations
🇺🇸

Maimonides Medical Center, Brooklyn, New York, United States

Non-invasive Early Goal Directed Therapy in Colorectal Surgery: a Feasibility Study

Not Applicable
Completed
Conditions
Perioperative/Postoperative Complications
C.Surgical Procedure; Digestive System
Interventions
First Posted Date
2015-09-24
Last Posted Date
2015-10-29
Lead Sponsor
University Hospital Schleswig-Holstein
Target Recruit Count
80
Registration Number
NCT02559141
Locations
🇩🇪

Ole Broch, Kiel, Schleswig-Holstein, Germany

Myocardial Regional Function by Dobutamine Stress Echocardiography in the Metabolic Syndrome and Type 2 Diabetes

Not Applicable
Completed
Conditions
Diabetes-related Complications
Interventions
First Posted Date
2015-07-22
Last Posted Date
2019-01-18
Lead Sponsor
University of Avignon
Target Recruit Count
125
Registration Number
NCT02505451
Locations
🇫🇷

Hospital Henri Duffaut, Avignon, Paca, France

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