Chloroprocaine

Generic Name
Chloroprocaine
Brand Names
Clorotekal, Iheezo, Nesacaine
Drug Type
Small Molecule
Chemical Formula
C13H19ClN2O2
CAS Number
133-16-4
Unique Ingredient Identifier
5YVB0POT2H
Background

Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of chloroprocaine i...

Indication

Chloroprocaine for intrathecal injection is indicated for the production of subarachnoid block (spinal anesthesia) in adults. It is also indicated for the production of local anesthesia by infiltration, peripheral and central nerve block, and a preservative-free form can also be used for lumbar and caudal epidural blocks. Topical chloroprocaine for ophthalmi...

Associated Conditions
-
Associated Therapies
Infiltration anesthesia therapy, Local Anaesthesia therapy, Ocular surface anesthesia, Peripheral Nerve Blocks, Spinal Anesthesia therapy, Caudal epidural block therapy, Lumbar epidural anesthesia therapy
Clinical Trials
Related News

Multicenter Study of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia

Phase 4
Not yet recruiting
Conditions
Obstetric Labor
Interventions
Drug: Chloroprocaine
First Posted Date
2024-06-25
Last Posted Date
2024-06-25
Lead Sponsor
Women's Hospital School Of Medicine Zhejiang University
Target Recruit Count
356
Registration Number
NCT06472232

Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine in Labor Epidural Analgesia.

First Posted Date
2024-03-08
Last Posted Date
2024-03-12
Lead Sponsor
Hadassah Medical Organization
Target Recruit Count
60
Registration Number
NCT06302257
Locations
🇮🇱

Hadassah Hebrew University Medical Center, POB 12000, Jerusalem, Israel

Optimizing Anesthesia for Post Partum Tubal Ligations

Phase 2
Terminated
Conditions
Pregnancy Related
Interventions
Drug: Bupivacaine
Drug: Chloroprocaine
First Posted Date
2019-06-20
Last Posted Date
2021-12-17
Lead Sponsor
University of Alabama at Birmingham
Target Recruit Count
15
Registration Number
NCT03993314
Locations
🇺🇸

University of Alabama at Birmingham, Birmingham, Alabama, United States

Chloroprocaine Spinal for Outpatient Knee Surgery

First Posted Date
2017-12-07
Last Posted Date
2022-04-20
Lead Sponsor
Hospital for Special Surgery, New York
Target Recruit Count
39
Registration Number
NCT03365752
Locations
🇺🇸

Hospital for Special Surgery, New York, New York, United States

Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage

Phase 4
Completed
Conditions
Cervical Incompetence
Interventions
Drug: Chloroprocaine
Drug: Bupivacaine
First Posted Date
2017-10-10
Last Posted Date
2020-08-25
Lead Sponsor
Tufts Medical Center
Target Recruit Count
10
Registration Number
NCT03305575
Locations
🇺🇸

Tufts Medical Center, Boston, Massachusetts, United States

Chloroprocaine 3% - Epidural Anesthesia in Unplanned Caesarean Section

First Posted Date
2016-09-29
Last Posted Date
2023-11-21
Lead Sponsor
Sintetica SA
Target Recruit Count
16
Registration Number
NCT02919072
Locations
🇧🇪

UZ Leuven, campus Gasthuisberg, Leuven, Belgium

Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)

First Posted Date
2016-08-11
Last Posted Date
2020-12-24
Lead Sponsor
Columbia University
Target Recruit Count
43
Registration Number
NCT02862912
Locations
🇺🇸

New York Presbyterian Hospital, New York, New York, United States

Spinal Anesthesia for Outpatient Abdominal Wall Surgery: Comparison of Bupivacaine, 2-chloroprocaine and Prilocaine

First Posted Date
2016-06-27
Last Posted Date
2016-06-28
Lead Sponsor
AZ St.-Dimpna Geel
Target Recruit Count
101
Registration Number
NCT02813382

Decision Support for Intraoperative Low Blood Pressure

Not Applicable
Completed
Conditions
Hypotension
Interventions
Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Sodium Chloride 0.9%
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Fresh Frozen Plasma
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine
First Posted Date
2016-04-04
Last Posted Date
2019-05-16
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
22435
Registration Number
NCT02726620
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

The Impact of Chloroprocaine 3% for Ambulatory Foot Surgery on Perioperative Process Costs

First Posted Date
2015-04-02
Last Posted Date
2020-03-11
Lead Sponsor
Ospedale Regionale Bellinzona e Valli
Target Recruit Count
100
Registration Number
NCT02406703
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