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Dobutamine

Generic Name
Dobutamine
Drug Type
Small Molecule
Chemical Formula
C18H23NO3
CAS Number
34368-04-2
Unique Ingredient Identifier
3S12J47372
Background

A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.

Indication

Indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.

Associated Conditions
Cardiac Decompensation, Coronary Artery Disease (CAD)
Associated Therapies
Intravenous inotropic therapy
Clinical Trials
Related News

The Effects of Dobutamine on Postoperative Cardiac Function in Aortic Valve Replacement

Phase 4
Suspended
Conditions
Heart Failure
Interventions
First Posted Date
2011-06-17
Last Posted Date
2013-08-07
Lead Sponsor
University of Aarhus
Target Recruit Count
10
Registration Number
NCT01375335
Locations
🇩🇰

Department of Anaesthesia & Intensive Care, Århus University Hospital, Århus, Denmark

Reduced Contractile Reserve: a Therapeutic Target in Heart Failure With Preserved Ejection Fraction(HFpEF)

Not Applicable
Completed
Conditions
Pulmonary Disease
Heart Failure With Preserved Ejection Fraction
Left Ventricular Hypertrophy/Hypertension
Interventions
First Posted Date
2011-05-17
Last Posted Date
2019-04-11
Lead Sponsor
University of Wisconsin, Madison
Target Recruit Count
14
Registration Number
NCT01354613
Locations
🇺🇸

UW - Madison, Madison, Wisconsin, United States

Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients

Not Applicable
Completed
Conditions
Septic Shock
Interventions
Drug: Placebo
First Posted Date
2011-01-06
Last Posted Date
2015-06-26
Lead Sponsor
Pontificia Universidad Catolica de Chile
Target Recruit Count
20
Registration Number
NCT01271153
Locations
🇨🇱

Hospital Clinico Universidad Catolica de Chile, Santiago, RM, Chile

Early Diagnosis of Diastolic Dysfunction and Reliability of DSE in Detecting Stress Diastolic Dysfunction

Not Applicable
Completed
Conditions
Diastolic Dysfunction
Interventions
First Posted Date
2009-10-20
Last Posted Date
2017-04-06
Lead Sponsor
University of Missouri-Columbia
Target Recruit Count
16
Registration Number
NCT00998205
Locations
🇺🇸

University of Missouri, Columbia, Missouri, United States

Effects of Levosimendan on Microcirculation in Septic Shock

Phase 2
Completed
Conditions
Septic Shock
Interventions
First Posted Date
2008-12-02
Last Posted Date
2009-10-15
Lead Sponsor
University of Roma La Sapienza
Target Recruit Count
40
Registration Number
NCT00800306
Locations
🇮🇹

Departement of Anesthesiology and Intensive Care of the University of Rome "La Sapienza" Viale del Policlinico 155, Rome, Italy

Comparison of Dobutamine and Regadenoson Stress Cardiac Magnetic Resonance (MR)

Early Phase 1
Terminated
Conditions
Coronary Artery Disease
Asthma
Chronic Obstructive Pulmonary Disease (COPD)
Angina
Interventions
First Posted Date
2008-09-30
Last Posted Date
2018-09-26
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
14
Registration Number
NCT00763035
Locations
🇺🇸

WAKE FOREST UNIVERSITY Baptist Medical Center, Winston-Salem, North Carolina, United States

Hemodynamics and Extravascular Lung Water in Acute Lung Injury

Phase 2
Completed
Conditions
Acute Lung Injury
Interventions
Drug: Diuresis (furosemide) part I
Other: Fluid Bolus (crystalloid or albumin)
Drug: Vasopressors (Norepinephrine, Vasopressin, Phenylephrine, Epinephrine)
Drug: Diuresis (furosemide) part II
Other: Concentrate all drips and nutrition
Procedure: Dialysis
First Posted Date
2008-02-27
Last Posted Date
2019-09-10
Lead Sponsor
Oregon Health and Science University
Target Recruit Count
33
Registration Number
NCT00624650
Locations
🇺🇸

Legacy Good Samaritan, Portland, Oregon, United States

🇺🇸

Oregon Health and Science University, Portland, Oregon, United States

🇺🇸

Kaiser Permanente Sunnyside, Clackamas, Oregon, United States

Cardiac Function Under Stress for Early Detection of the Right Ventricular Insufficiency After Repair of Tetralogy of Fallot

Phase 3
Terminated
Conditions
Tetralogy of Fallot
Interventions
First Posted Date
2007-11-29
Last Posted Date
2012-06-06
Lead Sponsor
Competence Network for Congenital Heart Defects
Target Recruit Count
53
Registration Number
NCT00564993
Locations
🇩🇪

Herzzentrum Leipzig, Klinik für Kinderkardiologie, Leipzig, Saxony, Germany

🇩🇪

Herz-und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, North Rhine-Westphalia, Germany

🇩🇪

Deutsches Kinderherzzentrum St. Augustin, Sankt Augustin, North Rhine-Westphalia, Germany

and more 8 locations

Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis

Phase 4
Conditions
Severe Sepsis
Microcirculation
First Posted Date
2007-06-08
Last Posted Date
2008-01-22
Lead Sponsor
Onze Lieve Vrouwe Gasthuis
Target Recruit Count
80
Registration Number
NCT00484133
Locations
🇳🇱

Onze Lieve Vrouwe Gasthuis, intensive care, Amsterdam, Netherlands

Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support: a Multicentre, Parallel-Group, Randomised, Double-Blind, Double-Dummy Study of Levosimendan Versus Dobutamine in Patients With Acute Heart Failure.

Phase 3
Completed
Conditions
Acute Heart Failure
First Posted Date
2006-07-04
Last Posted Date
2007-11-20
Lead Sponsor
Abbott
Target Recruit Count
1300
Registration Number
NCT00348504
Locations
🇺🇸

Global Medical Information - Abbott, Abbott Park, Illinois, United States

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